A predicted dimer-based polymorph of 10,11-dihydrocarbamazepine (Form IV)

被引:21
作者
Arlin, Jean-Baptiste [1 ]
Johnston, Andrea [1 ]
Miller, Gary J. [1 ]
Kennedy, Alan R. [2 ]
Price, Sarah L. [3 ]
Florence, Alastair J. [1 ]
机构
[1] Univ Strathclyde, Solid State Res Grp, Strathclyde Inst Pharm & Biomed Sci, Glasgow G4 0NR, Lanark, Scotland
[2] Univ Strathclyde, Dept Pure & Appl Chem, WestCHEM, Glasgow G1 1XL, Lanark, Scotland
[3] UCL, Dept Chem, London WC1H 0AJ, England
来源
CRYSTENGCOMM | 2010年 / 12卷 / 01期
基金
英国工程与自然科学研究理事会;
关键词
CRYSTAL-STRUCTURES; PARALLEL CRYSTALLIZATION; PACKING MOTIFS; CARBAMAZEPINE; SIMILARITY; PATTERNS;
D O I
10.1039/b914365c
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A novel polymorph of 10,11-dihydrocarbamazepine (form IV), which had been predicted to be thermodynamically feasible, was obtained from the vapour phase and displays an R-2(2)(8) hydrogen bonded dimer motif in contrast to the catemeric motifs in forms I-III.
引用
收藏
页码:64 / 66
页数:3
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