High density deletion mapping of bladder cancer localizes the putative tumor suppressor gene between loci D8S504 and D8S264 at chromosome 8p23.3

被引：42

作者：

Muscheck, M ^{[1
]}

Sükösd, F ^{[1
]}

Pesti, T ^{[1
]}

Kovacs, G ^{[1
]}

机构：

[1] Univ Heidelberg, Dept Urol, Oncol Mol Lab, D-69120 Heidelberg, Germany

来源：

LABORATORY INVESTIGATION | 2000年 / 80卷 / 07期

关键词：

D O I：

10.1038/labinvest.3780114

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Deletion of chromosome 8p is associated with the progression of bladder cancer. To identify the putative tumor suppressor gene locus we have analyzed 145 bladder cancers with 12 microsatellite markers for allelic changes at the chromosome 8p23.3 region. We mapped the smallest overlapping deletion to approximately 0.7 cM genetic distance between loci D8S504 and D8S264. Allelic changes at this region occurred in 75 (52%) of the 145 tumors. We found a significant correlation between alterations at chromosome 8p23.3 and the tumor grade. The correlation between genetic changes and tumor stage reflected the distribution of tumors of different grades in each pathologic stage.

引用

页码：1089 / 1093

页数：5

共 28 条

[11]

Ohgaki K, 1999, GENE CHROMOSOME CANC, V25, P1, DOI 10.1002/(SICI)1098-2264(199905)25:1<1::AID-GCC1>3.0.CO

[12]

2-3

[13]

ORLOW I, 1994, CANCER RES, V54, P2848

[14]

Perinchery G, 1999, INT J ONCOL, V14, P495

[15] Identification of three distinct regions of allelic deletions on the short arm of chromosome 8 in hepatocellular carcinoma [J].

Pineau, P ;

Nagai, H ;

Prigent, S ;

Wei, Y ;

Gyapay, G ;

Weissenbach, J ;

Tiollais, P ;

Buendia, MA ;

Dejean, A .

ONCOGENE, 1999, 18 (20) :3127-3134

[16]

Richter J, 1999, CANCER RES, V59, P5687

[17] Patterns of chromosomal imbalances in advanced urinary bladder cancer detected by comparative genomic hybridization [J].

Richter, J ;

Beffa, L ;

Wagner, U ;

Schraml, P ;

Gasser, TC ;

Moch, H ;

Mihatsch, MJ ;

Sauter, G .

AMERICAN JOURNAL OF PATHOLOGY, 1998, 153 (05) :1615-1621

[18]

Richter J, 1997, CANCER RES, V57, P2860

[19] Chromosome 8 allelic loss and the outcome of patients with squamous cell carcinoma of the supraglottic larynx [J].

Scholnick, SB ;

Haughey, BH ;

Sunwoo, JB ;

ElMofty, SK ;

Baty, JD ;

Piccirillo, JF ;

Zequeira, MR .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1996, 88 (22) :1676-1682

[20]

Simon R, 1998, J PATHOL, V185, P345

← 1 2 3 →