Psoriasis

被引：230

作者：

Di Meglio, Paola ^{[1
]}

Villanova, Federica ^{[2
,3
]}

Nestle, Frank O. ^{[2
,3
]}

机构：

[1] Natl Inst Med Res, MRC, London NW7 1AA, England

[2] Kings Coll London, St Johns Inst Dermatol, London SE1 9RT, England

[3] Guys & St Thomas Natl Hlth Serv Fdn Trust, Natl Inst Hlth Res, GSTT KCL Comprehens Biomed Res Ctr, London SE1 9RT, England

来源：

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2014年 / 4卷 / 08期

基金：

英国惠康基金;

关键词：

GENOME-WIDE ASSOCIATION; SEVERE PLAQUE PSORIASIS; RANDOMIZED CONTROLLED-TRIAL; PLACEBO-CONTROLLED TRIAL; INNATE LYMPHOID-CELLS; INTERLEUKIN-12/23; MONOCLONAL-ANTIBODY; JANUS KINASE INHIBITOR; INFILTRATING T-CELLS; CONTROLLED PHASE-III; DOUBLE-BLIND;

D O I：

10.1101/cshperspect.a015354

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Psoriasis is a common chronic inflammatory skin disease with a spectrum of clinical phenotypes and results from the interplay of genetic, environmental, and immunological factors. Four decades of clinical and basic research on psoriasis have elucidated many of the pathogenic mechanisms underlying disease and paved the way to effective targeted therapies. Here, we review this progress and identify future directions of study that are supported by a more integrative research approach and aim at further improving the patients' life.

引用

页数：30

共 253 条

[1] Psoriasis is associated with clinically significant cardiovascular risk: a Danish nationwide cohort study [J].