Viral RNA Metagenomics of Hyalomma Ticks Collected from Dromedary Camels in Makkah Province, Saudi Arabia

被引:24
|
作者
Zakham, Fathiah [1 ,2 ,3 ,9 ]
Albalawi, Aishah E. [4 ]
Alanazi, Abdullah D. [5 ]
Phuoc Truong Nguyen [1 ]
Alouffi, Abdulaziz S. [6 ]
Alaoui, Altaf [7 ]
Sironen, Tarja [1 ,2 ]
Smura, Teemu [1 ,8 ]
Vapalahti, Olli [1 ,2 ,8 ]
机构
[1] Univ Helsinki, Fac Med, Dept Virol, Helsinki 00014, Finland
[2] Univ Helsinki, Fac Vet Med, Dept Vet Biosci, Helsinki 00014, Finland
[3] Univ Helsinki, Fac Pharm, Helsinki 00014, Finland
[4] Univ Tabuk, Fac Sci, Dept Biol, Tabuk 47912, Saudi Arabia
[5] Shaqra Univ, Fac Sci & Humanities, Dept Biol Sci, Ad Dawadimi 11911, Saudi Arabia
[6] King Abdulaziz City Sci & Technol, Riyadh 12354, Saudi Arabia
[7] Ibn Tofail Univ, Lab Engn Sci & Modeling, Kenitra 14000, Morocco
[8] Hosp Dist Helsinki & Uusimaa, HUS Diagnost Ctr, HUSLAB, Helsinki 00260, Finland
[9] Univ Helsinki, Med, Dept Virol, POB 21,Haartmaninkatu 3, Helsinki 00014, Finland
来源
VIRUSES-BASEL | 2021年 / 13卷 / 07期
基金
芬兰科学院;
关键词
virome analysis; Hyalomma dromedarii; dromedary camels; province of Makkah; Saudi Arabia; arboviruses; tick-borne diseases; HEMORRHAGIC-FEVER VIRUS; TAMDY VIRUS; COMPLEX; ASIA;
D O I
10.3390/v13071396
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Arthropod-borne infections are a medical and economic threat to humans and livestock. Over the last three decades, several unprecedented viral outbreaks have been recorded in the Western part of the Arabian Peninsula. However, little is known about the circulation and diversity of arthropod-borne viruses in this region. To prepare for new outbreaks of vector-borne diseases, it is important to detect which viruses circulate in each vector population. In this study, we used a metagenomics approach to characterize the RNA virome of ticks infesting dromedary camels (Camelus dromedaries) in Makkah province, Saudi Arabia. Two hundred ticks of species Hyalomma dromedarii (n = 196) and Hyalomma impeltatum (n = 4) were collected from the Alkhurma district in Jeddah and Al-Taif city. Virome analysis showed the presence of several tick-specific viruses and tick-borne viruses associated with severe illness in humans. Some were identified for the first time in the Arabian Peninsula. The human disease-associated viruses detected included Crimean Congo Hemorrhagic fever virus and Tamdy virus (family Nairoviridae), Guertu virus (family Phenuiviridae), and a novel coltivirus that shares similarities with Tarumizu virus, Tai forest reovirus and Kundal virus (family Reoviridae). Furthermore, Alkhurma hemorrhagic virus (Flaviviridae) was detected in two tick pools by specific qPCR. In addition, tick-specific viruses in families Phenuiviridae (phleboviruses), Iflaviridae, Chuviridae, Totiviridae and Flaviviridae (Pestivirus) were detected. The presence of human pathogenetic viruses warrants further efforts in tick surveillance, xenosurveillence, vector control, and sero-epidemiological investigations in human and animal populations to predict, contain and mitigate future outbreaks in the region.
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页数:13
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