Altered Cerebellum Spontaneous Activity in Juvenile Autism Spectrum Disorders Associated with Clinical Traits

被引：14
作者：
Li, Jinglun [1 ,2 ]
Chen, Xiu [1 ,2 ]
Zheng, Ruwen [3 ]
Chen, Ai [4 ,5 ]
Zhou, Yan [1 ,2 ,6 ]
Ruan, Jianghai [1 ,2 ]
机构：
[1] Southwest Med Univ, Dept Neurol, Affiliated Hosp, Taiping St 25, Luzhou 646000, Peoples R China
[2] Lab Neurol Dis & Brain Funct, Luzhou 646000, Peoples R China
[3] Beijing Univ Chinese Med, Dongfang Hosp, Dept Acupuncture & Moxibust, Beijing 100071, Peoples R China
[4] Sichuan Prov Hosp Women & Children, Dept Pediat, Chengdu 610041, Peoples R China
[5] Sichuan Clin Res Ctr Birth Defects, Luzhou 646000, Peoples R China
[6] Jianyang Peoples Hosp, Dept Neurol, Jianyang 646000, Peoples R China
来源：
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2022年 / 52卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Autism spectrum disorders; Amplitude of low-frequency fluctuations; Cerebellum; Functional magnetic resonance imaging; SPONTANEOUS BRAIN ACTIVITY; FUNCTIONAL CONNECTIVITY; STATE; CHILDREN; CORTEX; ANATOMY; VOLUMES;
D O I：
10.1007/s10803-021-05167-6
中图分类号：
B844 [发展心理学（人类心理学）];
学科分类号：
040202 ;
摘要：
Autism spectrum disorder (ASD) is a neurodevelopmental disorder. The associations between the cerebellum and clinical traits remain unclear. We performed amplitude of low-frequency fluctuation (ALFF) analysis to explore the associations between spontaneous brain activity and clinical traits. 361 juvenile ASD patients were included from the ABIDEII database. In the ASD group, the mean ALFF values of cerebellum 4 5 were correlated with SRS awareness and communication. The mean ALFF values of cerebellum 6 and vermis 4 5 were both positively correlated with SRS total, awareness, communication, and motivation. In contrast, the mean ALFF values of vermis 1 2 were negatively correlated with SRS total, awareness, and mannerisms. Our study suggests a role of the cerebellum in functional impairments in ASD.
引用
收藏
页码：2497 / 2504
页数：8
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