Effectiveness of Whole, Inactivated, Low Pathogenicity Influenza A( H7N9) Vaccine against Antigenically Distinct, Highly Pathogenic H7N9 Virus

被引：10

作者：

Hatta, Masato ^{[1
]}

Zhong, Gongxun ^{[2
]}

Chiba, Shiho ^{[2
]}

Lopes, Tiago J. S. ^{[2
]}

Neumann, Gabriele ^{[2
]}

Kawaoka, Yoshihiro ^{[2
,3
]}

机构：

[1] Univ Wisconsin, Influenza Res Inst, Madison, WI USA

[2] Univ Wisconsin, Madison, WI USA

[3] Univ Tokyo, Tokyo, Japan

来源：

EMERGING INFECTIOUS DISEASES | 2018年 / 24卷 / 10期

关键词：

5TH EPIDEMIC; CHINA;

D O I：

10.3201/eid2410.180403

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The recent emergence of highly pathogenic influenza A(H7N9) variants poses a great risk to humans. We show that ferrets vaccinated with low pathogenicity H7N9 virus vaccine do not develop severe symptoms after infection with an antigenically distinct, highly pathogenic H7N9 virus. These results demonstrate the protective benefits of this H7N9 vaccine.

引用

页码：1910 / 1913

页数：4

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