Circumventing failed antiviral immunity in chronic hepatitis B virus infection: triggering virus-specific or innate-like T cell response?

被引：13
作者：
Koh, Sarene [1 ]
Bertoletti, Antonio [1 ,2 ]
机构：
[1] ASTAR, Viral Hepatitis Unit, Singapore Inst Clin Sci, Singapore, Singapore
[2] Duke NUS Grad Med Sch, Program Emerging Viral Dis, Singapore, Singapore
来源：
MEDICAL MICROBIOLOGY AND IMMUNOLOGY | 2015年 / 204卷 / 01期
关键词：
Hepatitis B virus; Therapeutic vaccination; T cells; PLASMACYTOID DENDRITIC CELLS; COMPLEX THERAPEUTIC VACCINE; BONE-MARROW-TRANSPLANTATION; COLONY-STIMULATING FACTOR; HEPATOCELLULAR-CARCINOMA; PROGRAMMED DEATH-1; PEGINTERFERON ALPHA-2A; LYMPHOCYTE RESPONSE; INTERFERON-ALPHA; SURFACE-ANTIGEN;
D O I：
10.1007/s00430-014-0377-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Therapeutic vaccination for the treatment of chronic hepatitis B has thus far been unsatisfactory. In this review, we discuss potential new therapeutic vaccination strategies and other immunotherapeutic approaches that aim to achieve efficient restoration of HBV immunity in chronically infected patients.
引用
收藏
页码：87 / 94
页数：8
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