Endosomal trafficking in schizophrenia

被引：7

作者：

Plooster, Melissa ^{[1
]}

Brennwald, Patrick ^{[1
]}

Gupton, Stephanie L. ^{[1
]}

机构：

[1] Univ N Carolina, Dept Cell Biol & Physiol, Chapel Hill, NC 27515 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2022年 / 74卷

基金：

美国国家卫生研究院;

关键词：

ENDOCYTIC TRAFFICKING; COMPLEX; HERITABILITY; LOCALIZATION; PREVALENCE; DYSBINDIN; VARIANTS; PROTEINS; DTNBP1; BLOC-1;

D O I：

10.1016/j.conb.2022.102539

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Schizophrenia is a severe and heritable neuropsychiatric disorder, which arises due to a combination of common genetic variation, rare loss of function variation, and copy number variation. Functional genomic evidence has been used to identify candidate genes affected by this variation, which revealed biological pathways that may be disrupted in schizophrenia. Understanding the contributions of these pathways are critical next steps in understanding schizophrenia pathogenesis. A number of genes involved in endocytosis are implicated in schizophrenia. In this review, we explore the history of endosomal trafficking in schizophrenia and highlight new endosomal candidate genes. We explore the function of these candidate genes and hypothesize how their dysfunction may contribute to schizophrenia.

引用

页数：9

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