Cardiopulmonary recovery after COVID-19: an observational prospective multicentre trial

被引：301

作者：

Sonnweber, Thomas ^{[1
]}

Sahanic, Sabina ^{[1
]}

Pizzini, Alex ^{[1
]}

Luger, Anna ^{[2
]}

Schwabl, Christoph ^{[2
]}

Sonnweber, Bettina ^{[3
]}

Kurz, Katharina ^{[1
]}

Koppelstatter, Sabine ^{[1
]}

Haschka, David ^{[1
]}

Petzer, Verena ^{[4
]}

Boehm, Anna ^{[1
]}

Aichner, Magdalena ^{[1
]}

Tymoszuk, Piotr ^{[1
]}

Lener, Daniela ^{[5
]}

Theurl, Markus ^{[5
]}

Lorsbach-Koehler, Almut ^{[1
]}

Tancevski, Amra ^{[1
]}

Schapfl, Anna ^{[3
]}

Schaber, Marc ^{[3
]}

Hilbe, Richard ^{[1
]}

Nairz, Manfred ^{[1
]}

Puchner, Bernhard ^{[6
]}

Huettenberger, Doris ^{[1
]}

Tschurtschenthaler, Christoph ^{[1
]}

Asshoff, Malte ^{[1
]}

Peer, Andreas ^{[7
]}

Hartig, Frank ^{[7
]}

Bellmann, Romuald ^{[7
]}

Joannidis, Michael ^{[7
]}

Gollmann-Tepekoylu, Can ^{[8
]}

Holfeld, Johannes ^{[8
]}

Feuchtner, Gudrun ^{[2
]}

Egger, Alexander ^{[9
]}

Hoermann, Gregor ^{[9
,10
,11
]}

Schroll, Andrea ^{[1
]}

Fritsche, Gernot ^{[1
]}

Wildner, Sophie ^{[1
]}

Bellmann-Weiler, Rosa ^{[1
]}

Kirchmair, Rudolf ^{[5
,6
]}

Helbok, Raimund ^{[12
]}

Prosch, Helmut ^{[13
]}

Rieder, Dietmar ^{[14
]}

Trajanoski, Zlatko ^{[14
]}

Kronenberg, Florian ^{[15
]}

Woell, Ewald ^{[3
]}

Weiss, Gunter ^{[1
]}

Widmann, Gerlig ^{[2
]}

Loeffler-Ragg, Judith ^{[1
]}

Tancevski, Ivan ^{[1
]}

机构：

[1] Med Univ Innsbruck, Dept Internal Med 2, Innsbruck, Austria

[2] Med Univ Innsbruck, Dept Radiol, Innsbruck, Austria

[3] St Vinzenz Hosp, Dept Internal Med, Zams, Austria

[4] Med Univ Innsbruck, Dept Internal Med 5, Innsbruck, Austria

[5] Med Univ Innsbruck, Dept Internal Med 3, Innsbruck, Austria

[6] Reha Zentrum Munster, Karl Landsteiner Inst, Munster, Austria

[7] Med Univ Innsbruck, Dept Internal Med 1, Div Intens Care & Emergency Med, Innsbruck, Austria

[8] Med Univ Innsbruck, Dept Cardiac Surg, Innsbruck, Austria

[9] Univ Hosp Innsbruck, Cent Inst Med & Chem Lab Diagnost, Innsbruck, Austria

[10] Med Univ Vienna, Dept Lab Med, Vienna, Austria

[11] MLL Munich Leukemia Lab, Munich, Germany

[12] Med Univ Innsbruck, Dept Neurol, Innsbruck, Austria

[13] Med Univ Vienna, Dept Biomed Imaging & Image Guided Therapy, Vienna, Austria

[14] Med Univ Innsbruck, Inst Bioinformat, Innsbruck, Austria

[15] Med Univ Innsbruck, Inst Genet Epidemiol, Innsbruck, Austria

来源：

EUROPEAN RESPIRATORY JOURNAL | 2021年 / 57卷 / 04期

关键词：

ACUTE RESPIRATORY SYNDROME; QUALITY-OF-LIFE; PULMONARY-FUNCTION; EXERCISE CAPACITY; SYNDROME SARS; OUTCOMES; IMPACT; SURVIVORS; COHORT;

D O I：

10.1183/13993003.03481-2020

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background: After the 2002/2003 severe acute respiratory syndrome outbreak, 30% of survivors exhibited persisting structural pulmonary abnormalities. The long-term pulmonary sequelae of coronavirus disease 2019 (COVID-19) are yet unknown, and comprehensive clinical follow-up data are lacking.& nbsp; Methods: In this prospective, multicentre, observational study, we systematically evaluated the cardiopulmonary damage in subjects recovering from COVID-19 at 60 and 100 days after confirmed diagnosis. We conducted a detailed questionnaire, clinical examination, laboratory testing, lung function analysis, echocardiography and thoracic low-dose computed tomography (CT).& nbsp; Results: Data from 145 COVID-19 patients were evaluated, and 41% of all subjects exhibited persistent symptoms 100 days after COVID-19 onset, with dyspnoea being most frequent (36%). Accordingly, patients still displayed an impaired lung function, with a reduced diffusing capacity in 21% of the cohort being the most prominent finding. Cardiac impairment, including a reduced left ventricular function or signs of pulmonary hypertension, was only present in a minority of subjects. CT scans unveiled persisting lung pathologies in 63% of patients, mainly consisting of bilateral ground-glass opacities and/or reticulation in the lower lung lobes, without radiological signs of pulmonary fibrosis. Sequential follow-up evaluations at 60 and 100 days after COVID-19 onset demonstrated a vast improvement of symptoms and CT abnormalities over time.& nbsp; Conclusion: A relevant percentage of post-COVID-19 patients presented with persisting symptoms and lung function impairment along with radiological pulmonary abnormalities >100 days after the diagnosis of COVID-19. However, our results indicate a significant improvement in symptoms and cardiopulmonary status over time.

引用

页数：11

共 32 条

[1] Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19 [J].