Dramatic bone remodeling following larotrectinib administration for bone metastasis in a patient with TRK fusion congenital mesoblastic nephroma

被引：28

作者：

Halalsheh, Hadeel ^{[1
]}

McCarville, Mary Beth ^{[2
]}

Neel, Michael ^{[3
]}

Reynolds, Mark ^{[4
]}

Cox, Michael C. ^{[4
]}

Pappo, Alberto S. ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Oncol, 262 Danny Thomas Pl, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Dept Diagnost Imaging, 332 N Lauderdale St, Memphis, TN 38105 USA

[3] St Jude Childrens Res Hosp, Dept Surg, 332 N Lauderdale St, Memphis, TN 38105 USA

[4] Loxo Oncol Inc, San Francisco, CA USA

来源：

PEDIATRIC BLOOD & CANCER | 2018年 / 65卷 / 10期

关键词：

bone metastasis; ETV6-NTRK; larotrectinib; mesoplastic nephroma; TRK inhibitor; ETV6-NTRK3 GENE FUSION; INFANTILE FIBROSARCOMA; RECURRENT; INFANCY;

D O I：

10.1002/pbc.27271

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mesoblastic nephroma is the most frequent renal tumor in newborns and young infants, and the cellular type is characterized by an ETV6-NTRK fusion, which constitutively activates the tropomyosin-related kinase (TRK) signaling pathway. Larotrectinib is a highly selective TRK inhibitor with activity in adult and pediatric patients who have TRK fusions. We present a rare case of a patient with mesoblastic nephroma metastatic to bone who had a dramatic response to larotrectinib.

引用

页数：3

共 2 条

[1] An unusual fusion gene EML4-ALK in a patient with congenital mesoblastic nephroma
Misove, Adela
Vicha, Ales
Zapotocky, Michal
Malis, Josef
Balko, Jan
Nemeckova, Tereza
Szabova, Jana
Kyncl, Martin
Novakova-Kodetova, Daniela
Stolova, Lucie
Jencova, Pavla
Broz, Petr
Krskova, Lenka
GENES CHROMOSOMES & CANCER, 2021, 60 (12) : 837 - 840
[2] A patient with esophageal cancer with bone metastasis who achieved pain relief with repetitive administration of strontium-89 chloride
Maeda O.
Ando T.
Ishiguro K.
Watanabe O.
Miyahara R.
Nakamura M.
Funasaka K.
Furukawa K.
Ando Y.
Kato K.
Goto H.
Clinical Journal of Gastroenterology, 2014, 7 (5) : 387 - 391

← 1 →