Synthesis of tacrine derivatives under solventless conditions

被引：19

作者：

Khalilzadeh, Mohammad A. ^{[1
]}

Hosseini, Abolfazl ^{[1
]}

Tajbakhsh, Mahmoud ^{[1
]}

机构：

[1] Islamic Azad Univ, Dept Chem, Qaemshahr, Iran

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2007年 / 44卷 / 03期

关键词：

D O I：

10.1002/jhet.5570440305

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Effects of microwave irradiation on the solid-phase synthesis of tacrine and its derivatives have been evaluated. Preparation of tacrine analogues under conventional conditions suffers from poor synthetic efficiency and usually gives low yield. Reaction of substituted anthranilonitrile with cyclohexanone under microwave irradiation gave a good to excellent yield of the corresponding substituted 9-amino-1,2,3,4-tetrahydroacridines.

引用

页码：535 / 538

页数：4

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