Metal-Free Highly Regioselective Aminotrifluoroacetoxylation of Alkenes

被引：151

作者：

Lovick, Helena M. ^{[1
]}

Michael, Forrest E. ^{[1
]}

机构：

[1] Univ Washington, Dept Chem, Seattle, WA 98195 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 04期

基金：

美国国家科学基金会;

关键词：

HYPERVALENT IODINE REAGENTS; SHARPLESS ASYMMETRIC AMINOHYDROXYLATION; OLEFIN AMIDOHYDROXYLATION; OXIDATIVE CYCLIZATION; ORGANIC-SYNTHESIS; AZIRIDINATION; PIPERIDINES; PALLADIUM; (+)-PSEUDOCONHYDRINE; ALKALOIDS;

D O I：

10.1021/ja906648w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a highly regioselective metal-free oxidative cyclization of sulfonamides onto tethered, unactivated alkenes using hypervalent iodine and Bronsted acids. Under these conditions the acid counterion is incorporated into the cyclized products providing an overall aminotrifluoroacetoxylation of the alkene. An unusual preference for endo ring closure is exhibited in contrast to existing exo selective methods. Multiple ring sizes can be formed to access functionalized pyrrolidines, piperidines, and azepanes with a general preference for endo cyclization. A variety of substrate Substitution patterns were tolerated to provide nitrogen-containing heterocycles with high regioselectivities and good to excellent diastereoselectivities.

引用

页码：1249 / +

页数：5

共 44 条

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