Toward faster and higher resolution LA-ICPMS imaging: on the co-evolution of LA cell design and ICPMS instrumentation

被引：76

作者：

Gundlach-Graham, Alexander ^{[1
]}

Guenther, Detlef ^{[1
]}

机构：

[1] ETH, Dept Chem & Appl Biosci, Vladimir Prelog Weg 1, CH-8093 Zurich, Switzerland

来源：

ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2016年 / 408卷 / 11期

关键词：

Laser ablation; ICPMS; Elemental imaging; Mass spectrometry; Time-of-flight; PLASMA-MASS SPECTROMETRY; LASER-ABLATION; HIGH-SPEED; SIGNAL; OPTIMIZATION; PERFORMANCE; PARTICLES; TORCH;

D O I：

10.1007/s00216-015-9251-8

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe trends in fast, high resolution elemental imaging by laser ablation-inductively coupled plasma mass spectrometry (LA-ICPMS). Recently developed low dispersion LA cells deliver quantitative transport of ablated aerosols within 10 ms and also provide enhanced sensitivity compared to conventional LA cells because the analyte ion signal becomes less diluted during aerosol transport. When connected to simultaneous ICPMS instruments, these low dispersion LA cells offer a platform for high speed and high lateral resolution shot-resolved LA-ICPMS imaging. Here, we examine the current paradigms of LA-ICPMS imaging and discuss how newly developed LA cell technology combined with simultaneous ICPMS instrumentation is poised to overcome current instrumental limitations to deliver faster, higher resolution elemental imaging.

引用

页码：2687 / 2695

页数：9

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