Metabolism and pharmacokinetics in children and the elderly

被引：5
作者：
Pelkonen, Olavi [1 ]
机构：
[1] Univ Oulu, Dept Pharmacol & Toxicol, FIN-90014 Oulu, Finland
来源：
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY | 2007年 / 3卷 / 02期
关键词：
age; children; development; drug metabolism; elderly; pharmacokinetics;
D O I：
10.1517/17425255.3.2.147
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
in drug development, clinical trials are commonly carried out in either healthy volunteers or carefully selected patients. However, it has been recognised for a long time that both extremes of age, children and elderly, display a number of important metabolic and pharmacokinetic differences as compared with adults. This also has important consequences as to the toxic reactions and risk assessment of chemicals. What is known, what is not known and what should we do to improve the situation?
引用
收藏
页码：147 / 148
页数：2
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