Metabolism and pharmacokinetics in children and the elderly

被引：5
|
作者：
Pelkonen, Olavi [1 ]
机构：
[1] Univ Oulu, Dept Pharmacol & Toxicol, FIN-90014 Oulu, Finland
来源：
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY | 2007年 / 3卷 / 02期
关键词：
age; children; development; drug metabolism; elderly; pharmacokinetics;
D O I：
10.1517/17425255.3.2.147
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
in drug development, clinical trials are commonly carried out in either healthy volunteers or carefully selected patients. However, it has been recognised for a long time that both extremes of age, children and elderly, display a number of important metabolic and pharmacokinetic differences as compared with adults. This also has important consequences as to the toxic reactions and risk assessment of chemicals. What is known, what is not known and what should we do to improve the situation?
引用
收藏
页码：147 / 148
页数：2
相关论文
共 50 条
  • [1] Pharmacokinetics and drug metabolism in the elderly
    Klotz, Ulrich
    DRUG METABOLISM REVIEWS, 2009, 41 (02) : 67 - 76
  • [2] Pharmacokinetics and drug metabolism of antibiotics in the elderly
    Pea, Federico
    EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, 2018, 14 (10) : 1087 - 1100
  • [3] PHARMACOKINETICS OF DRUGS IN THE ELDERLY
    WOODHOUSE, KW
    JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, 1994, 87 : 2 - 4
  • [4] Pharmacokinetics in the elderly
    Péhourcq, F
    Molimard, M
    REVUE DES MALADIES RESPIRATOIRES, 2002, 19 (03) : 356 - 362
  • [5] PHARMACOKINETICS OF NORFLOXACIN IN THE ELDERLY
    LEPAGE, JY
    CAILLON, J
    MALINOWSKY, JM
    LEQUERRE, S
    COZIAN, A
    LENORMAND, Y
    POTEL, G
    DRUGEON, H
    BARON, D
    FUNDAMENTAL & CLINICAL PHARMACOLOGY, 1991, 5 (03) : 203 - 208
  • [6] The Brain and Propranolol Pharmacokinetics in the Elderly
    Eugene, Andy R.
    Nicholson, Wayne T.
    BRAIN-BROAD RESEARCH IN ARTIFICIAL INTELLIGENCE AND NEUROSCIENCE, 2015, 6 (1-2): : 5 - +
  • [7] PHARMACOKINETICS OF CHLORMEZANONE IN ELDERLY PATIENTS
    BERNARD, N
    FAUVEL, JP
    POZET, N
    FERRY, N
    CUISINAUD, G
    HAOND, P
    CHAPUY, P
    SASSARD, J
    EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1991, 41 (06) : 603 - 607
  • [8] Single-Dose Pharmacokinetics and Metabolism of the Oral Decongestant Phenylephrine HCl in Children and Adolescents
    Gelotte, Cathy K. K.
    Parasrampuria, Dolly A. A.
    Zimmerman, Brenda A. A.
    PULMONARY THERAPY, 2023, 9 (01) : 139 - 150
  • [9] An insight into pharmacokinetics and dose optimization of antimicrobials agents in elderly patients
    Fu, Guanshuang
    Sun, Weijia
    Tan, Zhaoyi
    Liang, Beibei
    Cai, Yun
    FRONTIERS IN PHARMACOLOGY, 2024, 15
  • [10] Clinical pharmacokinetics of quinine and its relationship with treatment outcomes in children, pregnant women, and elderly patients, with uncomplicated and complicated malaria: a systematic review
    Saeheng, Teerachat
    Na-Bangchang, Kesara
    MALARIA JOURNAL, 2022, 21 (01)
12345