Gut Microbiota: Therapeutic Targets of Ginseng Against Multiple Disorders and Ginsenoside Transformation

被引：55

作者：

Chen, Zhaoqiang ^{[1
]}

Zhang, Zepeng ^{[2
,3
]}

Liu, Jiaqi ^{[1
]}

Qi, Hongyu ^{[1
]}

Li, Jing ^{[1
]}

Chen, Jinjin ^{[1
]}

Huang, Qingxia ^{[1
,2
]}

Liu, Qing ^{[1
]}

Mi, Jia ^{[4
]}

Li, Xiangyan ^{[1
]}

机构：

[1] Changchun Univ Chinese Med, Jilin Ginseng Acad, Key Lab Act Subst & Biol Mech Ginseng Efficacy, Jilin Prov Key Lab Biomacromol Chinese Med, Changchun, Peoples R China

[2] Changchun Univ Chinese Med, Affiliated Hosp 1, Res Ctr Tradit Chinese Med, Changchun, Peoples R China

[3] Changchun Univ Chinese Med, Coll Acupuncture & Tuina, Changchun, Peoples R China

[4] Changchun Univ Chinese Med, Affiliated Hosp 1, Dept Endocrinol, Changchun, Peoples R China

来源：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2022年 / 12卷

基金：

中国国家自然科学基金;

关键词：

ginseng (Panax ginseng C; A; Meyer); gut microbiota; multiple disorders; gisenoside transformation; ginsenoside; FATTY LIVER-DISEASE; KOREAN RED GINSENG; PANAX-GINSENG; COMPOUND K; DIABETES-MELLITUS; BETA-GLUCOSIDASE; ANALYSIS REVEALS; INDUCED DIARRHEA; ESSENTIAL OIL; CANCER-CELLS;

D O I：

10.3389/fcimb.2022.853981

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Panax ginseng, as the king of Chinese herb, has significant therapeutic effects on obesity, type 2 diabetes mellitus, fatty liver disease, colitis, diarrhea, and many other diseases. This review systematically summarized recent findings, which show that ginseng plays its role by regulating gut microbiota diversity, and gut microbiota could also regulate the transformation of ginsenosides. We conclude the characteristics of ginseng in regulating gut microbiota, as the potential targets to prevent and treat metabolic diseases, colitis, neurological diseases, cancer, and other diseases. Ginseng treatment can increase some probiotics such as Bifidobacterium, Bacteroides, Verrucomicrobia, Akkermansia, and reduce pathogenic bacteria such as Deferribacters, Lactobacillus, Helicobacter against various diseases. Meanwhile, Bacteroides, Eubacterium, and Bifidobacterium were found to be the key bacteria for ginsenoside transformation in vivo. Overall, ginseng can regulate gut microbiome diversity, further affect the synthesis of secondary metabolites, as well as promote the transformation of ginsenosides for improving the absorptivity of ginsenosides. This review can provide better insight into the interaction of ginseng with gut microbiota in multiple disorders and ginsenoside transformation.

引用

页数：18

共 122 条

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