Regulation of autophagy by polyphenols: Paving the road for treatment of neurodegeneration

被引：52

作者：

Nabavi, Seyed Fazel ^{[1
]}

Sureda, Antoni ^{[2
,3
]}

Dehpour, Ahmad Reza ^{[4
,5
]}

Shirooie, Samira ^{[6
]}

Silva, Ana Sanches ^{[7
,8
]}

Devi, Kasi Pandima ^{[9
]}

Ahmed, Touqeer ^{[10
]}

Ishaq, Nafeesa ^{[10
]}

Hashim, Rabia ^{[10
]}

Sobarzo-Sanchez, Eduardo ^{[11
,12
]}

Daglia, Maria ^{[13
]}

Braidy, Nady ^{[14
]}

Volpicella, Mariateresa ^{[15
]}

Vacca, Rosa Anna ^{[16
]}

Nabavi, Seyed Mohammad ^{[1
]}

机构：

[1] Baqiyatallah Univ Med Sci, Appl Biotechnol Res Ctr, POB 19395-5487, Tehran 1435916471, Iran

[2] Univ Balearic Islands, Res Grp Community Nutr & Oxidat Stress NUCOX, E-07122 Palma de Mallorca, Balearic Island, Spain

[3] Univ Balearic Islands, CIBEROBN, E-07122 Palma de Mallorca, Balearic Island, Spain

[4] Univ Tehran Med Sci, Fac Med, Dept Pharmacol, Tehran, Iran

[5] Univ Tehran Med Sci, Expt Med Res Ctr, Tehran, Iran

[6] Kermanshah Univ Med Sci, Sch Pharm, Kermanshah 6734667149, Iran

[7] Natl Inst Agr & Vet Res INIAV, P-4480 Vila do Conde, Portugal

[8] Univ Porto, ICETA, Ctr Study Anim Sci CECA, P-4051401 Oporto, Portugal

[9] Alagappa Univ, Dept Biotechnol, Karaikkudi 630003, Tamil Nadu, India

[10] Natl Univ Sci & Technol, Alta ur Rahrnan Sch Appl Biosci, Islamabad, Pakistan

[11] Univ Santiago de Compostela, Fac Pharm, Lab Pharmaceut Chem, Santiago De Compostela 15782, Spain

[12] Univ Cent Chile, Fac Ciencias Salud, Inst Invest & Innovac Salud, Santiago, Chile

[13] Univ Pavia, Dept Drug Sci, Med Chem & Pharmaceut Technol Sect, I-27100 Pavia, Italy

[14] Univ New South Wales, Sch Psychiat, Ctr Hlth Brain Ageing, Sydney, NSW, Australia

[15] Univ Bari, Dept Biosci Biotechnol & Biopharmaceut, Bari, Italy

[16] CNR, Inst Biomembranes Bioenerget & Mol Biotechnol, Bari, Italy

来源：

BIOTECHNOLOGY ADVANCES | 2018年 / 36卷 / 06期

关键词：

Alzheimer's disease; Autophagy; Parkinson's disease; Polyphenols; Neurodegeneration; NF-KAPPA-B; ALPHA-SYNUCLEIN; ALZHEIMERS-DISEASE; MUTANT-HUNTINGTIN; AMYLOID-BETA; CELL-DEATH; INDUCED NEUROTOXICITY; MEDIATED AUTOPHAGY; PARKINSONS-DISEASE; PLANT POLYPHENOLS;

D O I：

10.1016/j.biotechadv.2017.12.001

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In the present paper, we will discuss on the importance of autophagy in the central nervous system, and outline the relation between autophagic pathways and the pathogenesis of neurodegenerative disorders. The potential therapeutic benefits of naturally occurring phytochemicals as pharmacological modulators of autophagy will also be addressed. Our findings provide renewed insight on the molecular modes of protection by polyphenols, which is likely to be at least in part mediated not only by their potent antioxidant and anti-inflammatory effects, but also through modulation of autophagic processes to remove the aberrant protein aggregates.

引用

页码：1768 / 1778

页数：11

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