Extrapituitary effects of GnRH antagonists in assisted reproduction: a review

被引：15
|
作者：
Engel, J
Riethmoller-Winzen, H
Diedrich, K
机构：
[1] Univ Schleswig Holstein, Clin Hosp, Dept Gynecol & Obstet, D-23538 Lubeck, Germany
[2] Dr Riethmuller MRS GmbH, D-60318 Frankfurt, Germany
来源：
REPRODUCTIVE BIOMEDICINE ONLINE | 2005年 / 10卷 / 02期
关键词：
cetrorelix; direct effects; endometrium; IVF; ovary;
D O I：
10.1016/S1472-6483(10)60945-5
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
GnRH antagonists are used to prevent premature LH surges in assisted reproduction. The pregnancy rates obtained in several studies have been similar to those obtained in the long protocol with gonadotroph in-re leasing hormone (GnRH) agonists. However, lower oestrogen serum concentrations have been observed and fewer oocytes retrieved using GnRH antagonists. Thus, potential effects at extrapituitary GnRH receptors in the ovary and the endometrium have been claimed. The article reviews the currently available data from the literature as well as current investigations with respect to effects of cetrorelix on the ovary and the endometrium. No evidence was found to support the hypothesis of extrapituitary effects of GnRH antagonists such as cetrorelix at doses used in assisted reproduction.
引用
收藏
页码：230 / 234
页数：5
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