Role of hippocampal α2A-adrenergic receptor in methamphetamine-induced hyperlocomotion in the mouse

被引：3

作者：

Nishio, M ^{[1
]}

Kuroki, Y ^{[1
]}

Watanabe, Y ^{[1
]}

机构：

[1] Natl Def Med Coll, Dept Pharmacol, Tokorozawa, Saitama 3598513, Japan

来源：

NEUROSCIENCE LETTERS | 2003年 / 341卷 / 02期

关键词：

adrenergic receptor; hippocampus; methamphetamine; locomotion; anti-sense;

D O I：

10.1016/S0304-3940(03)00171-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Psychostimulants, such as methamphetamine (METH), induce psychological dependence and we recently suggested that hippocampal (alpha2A)-adrenergic receptor (alpha(2A)-AR) is involved in METH-induced modulation of central nervous systems. The present study shows that pretreatment with yohimbine dose-dependently decreased the ambulatory hyperactivities induced by METH (2 mg/kg) in mice. Moreover, specific knock-down of the hippocampal alpha(2A)-AR with infusion of anti-sense oligo DNA of alpha(2A)-AR significantly suppressed ambulatory activity induced by METH administration. Infusion of sense oligo DNA of alpha(2A)-AR into mouse hippocampus exerted no effects on the ambulatory activity. These observations strongly suggest the involvement of hippocampal alpha(2A)-AR in the regulation of ambulatory activity induced by METH administration. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：156 / 160

页数：5

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