Apolipoprotein E in temporal lobe epilepsy: A case-control study

被引:16
|
作者
Kumar, Amit
Tripathi, Manjari
Pandey, Ravindra M.
Ramakrishnan, Lakshmy
Srinivas, M.
Luthra, Kalpana
机构
[1] All India Inst Med Sci, Dept Biochem, New Delhi 110029, India
[2] All India Inst Med Sci, Dept Neurol, New Delhi 110029, India
[3] All India Inst Med Sci, Dept Biostat, New Delhi 110029, India
[4] All India Inst Med Sci, Dept Cardiac Biochem, New Delhi 110029, India
[5] All India Inst Med Sci, Dept Pediat Surg, New Delhi 110029, India
关键词
apolipoprotein E; gene polymorphism; plasma apo E levels; temporal lobe epilepsy; Asian Indians;
D O I
10.1155/2006/951632
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Purpose: To investigate the relationship of apolipoprotein E (apoE) genotype, plasma levels of apoE and lipids in temporal lobe epilepsy (TLE) patients in Asian Indians. Status of plasma levels of Apo E in epilepsy patients has not been reported till date. Methods: ApoE gene polymorphism was analyzed in 58 patients with temporal lobe epilepsy (TLE) and 57 age and sex approximated controls using Polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP). Levels of plasma apoE and lipids were measured using ELISA and enzymatic kits respectively. Results: The distribution of ApoE genotype in epilepsy patients and controls was comparable. Higher levels of plasma ApoE were observed in TLE patients as compared to controls (p = 0.0001). Individuals with plasma levels of apoE >190 mg/L were at 20 times higher odds (95%CI = 2.46-163.34, p = 0.005), while those with levels of apoE between 150-190 mg/L were at 4.9 times higher odds (95% CI = 1.85-13.9, p = 0.001), to develop TLE. Conclusions: We have observed for the first time, high levels of plasma apoE in epilepsy patients. The findings of this case-control study suggest that apolipoprotein E may play an important role in epilepsy.
引用
收藏
页码:335 / 342
页数:8
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