Involvement of two isoforms of SNAP-25 in the expression of long-term potentiation in the rat hippocampus

被引：31
作者：
Roberts, LA
Morris, BJ
O'Shaughnessy, CT
机构：
[1] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Receptor Syst, Stevenage SG1 2NY, Herts, England
[2] Univ Glasgow, Inst Biomed & Life Sci, Div Neurosci & Biomed Syst, Glasgow G12 8QQ, Lanark, Scotland
来源：
NEUROREPORT | 1998年 / 9卷 / 01期
关键词：
in situ hybridization; long-term potentiation; mRNA; SNAP-25;
D O I：
10.1097/00001756-199801050-00007
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
INDUCTION of long-term potentiation (LTP) in the hippocampus is associated with changes in expression of a variety of different proteins and is thought to be the mechanism which underlies synaptic plasticity. The 25 kDa synaptosomal-associated protein (SNAP-25) is a presynaptic protein which is involved in neurotransmitter exocytosis at the nerve terminal. Two isoforms of SNAP-25 have so far been identified (a and b) which differ in their distribution and developmental regulation. Using in situ hybridization, we demonstrated that the mRNA levels of the two isoforms of this protein are increased 2 h after the induction of LTP in granule cells of the dentate gyrus following high frequency stimulation of the perforant path in vivo. These observations further demonstrate the involvement of both isoforms of SNAP-25 in functional synaptic plasticity, although their exact roles have yet to be fully determined.
引用
收藏
页码：33 / 36
页数：4
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