The impact of automated hippocampal volumetry on diagnostic confidence in patients with suspected Alzheimer's disease: A European Alzheimer's Disease Consortium study

被引：27

作者：

Bosco, Paolo ^{[1
]}

Redolfi, Alberto ^{[1
]}

Bocchetta, Martina ^{[2
]}

Ferrari, Clarissa ^{[3
]}

Mega, Anna ^{[1
]}

Galluzzi, Samantha ^{[1
]}

Austin, Mark ^{[4
]}

Chincarini, Andrea ^{[5
]}

Collins, D. Louis ^{[6
,7
]}

Duchesne, Simon ^{[7
]}

Marechal, Benedicte ^{[8
,9
,10
]}

Roche, Alexis ^{[8
,9
,10
]}

Sensi, Francesco ^{[5
]}

Wolz, Robin ^{[4
]}

Alegret, Montserrat ^{[11
,12
]}

Assal, Frederic ^{[13
,14
]}

Balasa, Mircea ^{[15
]}

Bastin, Christine ^{[16
]}

Bougea, Anastasia ^{[17
]}

Emek-Savas, Derya Durusu ^{[18
,19
]}

Engelborghs, Sebastiaan ^{[20
,21
,22
]}

Grimmer, Timo ^{[23
]}

Grosu, Galina ^{[24
]}

Kramberger, Milica G. ^{[25
]}

Lawlor, Brian ^{[26
]}

Stojmenovic, Gorana Mandic ^{[27
]}

Marinescu, Mihaela ^{[28
]}

Mecocci, Patrizia ^{[29
]}

Molinuevo, Jose Luis ^{[15
]}

Morais, Ricardo ^{[30
]}

Niemantsverdriet, Ellis ^{[20
]}

Nobili, Flavio ^{[31
,32
]}

Ntovas, Konstantinos ^{[33
]}

O'Dwyer, Sarah ^{[26
]}

Paraskevas, George P. ^{[17
]}

Pelini, Luca ^{[29
]}

Picco, Agnese ^{[14
,31
,32
,34
,35
]}

Salmon, Eric ^{[16
]}

Santana, Isabel ^{[36
]}

Sotolongo-Grau, Oscar ^{[11
,12
]}

Spiru, Luiza ^{[37
,38
]}

Stefanova, Elka ^{[27
,39
]}

Popovic, Katarina Surlan ^{[40
]}

Tsolaki, Magda ^{[33
]}

Yener, Gorsev G. ^{[19
,41
,42
]}

Zekry, Dina ^{[14
,43
]}

Frisoni, Giovanni B. ^{[1
,14
,34
,35
]}

机构：

[1] IRCCS Ist Ctr S Giovanni Dio Fatebenefratelli, Lab Alzheimers Neuroimaging & Epidemiol, Brescia, Italy

[2] UCL Inst Neurol, Dementia Res Ctr, Dept Neurodegenerat Dis, London, England

[3] IRCCS Ist Ctr S Giovanni Dio Fatebenefratelli, Brescia, Italy

[4] IXICO Plc, London, England

[5] INFN, Genoa, Italy

[6] McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ, Canada

[7] True Posit Med Devices Inc, Quebec City, PQ, Canada

[8] Siemens Healthcare AG, Adv Clin Imaging Technol HC CMEA BM PI, Lausanne, Switzerland

[9] Univ Hosp CHUV, Dept Radiol, Lausanne, Switzerland

[10] Ecole Polytech Fed Lausanne, LTS5, Lausanne, Switzerland

[11] Inst Catala Neurociencies Aplicades, Fundacio ACE, Alzheimer Res Ctr, Barcelona, Spain

[12] Inst Catala Neurociencies Aplicades, Fundacio ACE, Memory Clin, Barcelona, Spain

[13] Univ Hosp, Geneva, Switzerland

[14] Univ Geneva, Geneva, Switzerland

[15] Hosp Clin Barcelona, Alzheimers & Other Cognit Disorder Unit, Barcelona, Spain

[16] Univ Liege, GIGA CRC In Vivo Imaging & Memory Clin, Liege, Belgium

[17] Kapodistrian Univ, Eginit Hosp, Dept Neurol 1, Med Sch Athens, Athens, Greece

[18] Dokuz Eylul Univ, Dept Psychol, Izmir, Turkey

[19] Dokuz Eylul Univ, Izmir Int Biomed & Genome Ctr, Izmir, Turkey

[20] Univ Antwerp, Reference Ctr Biol Markers Dementia BIODEM, Antwerp, Belgium

[21] Hosp Network Antwerp ZNA Hoge Beuken & Middelheim, Memory Clin, Antwerp, Belgium

[22] Hosp Network Antwerp ZNA Hoge Beuken & Middelheim, Dept Neurol, Antwerp, Belgium

[23] Tech Univ Munich, Klinikum Rechts Isar, Munich, Germany

[24] Elias Univ Clin Hosp, Radiol & Med Imagery, Bucharest, Romania

[25] Univ Med Ctr Ljubljana, Ctr Cognit Impairments, Dept Neurol, Ljubljana, Slovenia

[26] St James Hosp, Mercers Inst Successful Ageing, Dublin, Ireland

[27] CCS, Inst Neurol, Belgrade, Serbia

[28] Elias Univ Clin, Dept Geriatr Gerontol & Old Age Psychiat, Bucharest, Romania

[29] Univ Perugia, Ist Gerontol & Geriatria, Perugia, Italy

[30] Ctr Hosp & Univ Coimbra, Dept Med Imaging, Coimbra, Portugal

[31] Univ Genoa, Clin Neurol DINOGMI, Genoa, Italy

[32] IRCCS AOU San Martino IST, Genoa, Italy

[33] Aristotle Univ Thessaloniki, Dept Neurol 3, Thessaloniki, Greece

[34] Univ Hosp, Memory Clin, Geneva, Switzerland

[35] Univ Hosp, LANVIE Lab Neuroimaging Aging, Geneva, Switzerland

[36] Ctr Hosp & Univ Coimbra, Dept Neurol, Coimbra, Portugal

[37] Carol Davila Univ Med, Bucharest, Romania

[38] Ana Aslan Intl Fdn, Memory Clin, Bucharest, Romania

[39] Univ Belgrade, Fac Med, Belgrade, Serbia

[40] Univ Med Ctr Ljubljana, Clin Inst Radiol, Ljubljana, Slovenia

[41] Dokuz Eylul Univ, Dept Neurol, Izmir, Turkey

[42] Dokuz Eylul Univ, Brain Dynam Multidisciplinary Res Ctr, Izmir, Turkey

[43] Univ Hosp, Dept Internal Med Rehabil & Geriatr, Geneva, Switzerland

来源：

ALZHEIMERS & DEMENTIA | 2017年 / 13卷 / 09期

关键词：

Alzheimer's disease; Hippocampal volume; Biomarkers; Diagnostic confidence of AD; Medial temporal lobe atrophy; MILD COGNITIVE IMPAIRMENT; ASSOCIATION WORKGROUPS; NATIONAL INSTITUTE; CEREBROSPINAL-FLUID; MAGNETIC-RESONANCE; MCI PATIENTS; SEGMENTATION; BIOMARKERS; DEMENTIA; MRI;

D O I：

10.1016/j.jalz.2017.01.019

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Hippocampal volume is a core biomarker of Alzheimer's disease (AD). However, its contribution over the standard diagnostic workup is unclear. Methods: Three hundred fifty-six patients, under clinical evaluation for cognitive impairment, with suspected AD and Mini-Mental State Examination >= 20, were recruited across 17 European memory clinics. After the traditional diagnostic workup, diagnostic confidence of AD pathology (DCAD) was estimated by the physicians in charge. The latter were provided with the results of automated hippocampal volumetry in standardized format and DCAD was reassessed. Results: An increment of one interquartile range in hippocampal volume was associated with a mean change of DCAD of 28.0% (95% credible interval: [211.5, 25.0]). Automated hippocampal volumetry showed a statistically significant impact on DCAD beyond the contributions of neuropsychology, 18 F-fluorodeoxyglucose positron emission tomography/single-photon emission computed tomography, and cerebrospinal fluid markers (28.5, CrI: [211.5, 25.6]; 214.1, CrI: [219.3, 28.8]; 210.6, CrI: [214.6, 26.1], respectively). Discussion: There is a measurable effect of hippocampal volume on DCAD even when used on top of the traditional diagnostic workup. (C) 2017 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

引用

页码：1013 / 1023

页数：11

共 39 条

[1] The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease [J].

Albert, Marilyn S. ;

DeKosky, Steven T. ;

Dickson, Dennis ;

Dubois, Bruno ;

Feldman, Howard H. ;

Fox, Nick C. ;

Gamst, Anthony ;

Holtzman, David M. ;

Jagust, William J. ;

Petersen, Ronald C. ;

Snyder, Peter J. ;

Carrillo, Maria C. ;

Thies, Bill ;

Phelps, Creighton H. .

ALZHEIMERS & DEMENTIA, 2011, 7 (03) :270-279

[2] Relationship between hippbcampal atrophy and neuropathology markers: A 7T MRI validation study of the EADC-ADNI Harmonized Hippocampal Segmentation Protocol [J].

Apostolova, Liana G. ;

Zarow, Chris ;

Biado, Kristina ;

Hurtz, Sona ;

Boccardi, Marina ;

Somme, Johanne ;

Honarpisheh, Hedieh ;

Blanken, Anna E. ;

Brook, Jenny ;

Tung, Spencer ;

Kraft, Emily ;

Lo, Darrick ;

Ng, Denise ;

Alger, Jeffry R. ;

Vinters, Harry V. ;

Bocchetta, Martina ;

Duvernoy, Henri ;

Jack, Clifford R., Jr. ;

Frisoni, Giovanni B. .

ALZHEIMERS & DEMENTIA, 2015, 11 (02) :139-150

[3] Harmonized benchmark labels of the hippocampus on magnetic resonance: The EADC-ADNI project [J].

Bocchetta, Martina ;

Boccardi, Marina ;

Ganzola, Rossana ;

Apostolova, Liana G. ;

Preboske, Gregory ;

Wolf, Dominik ;

Ferrari, Clarissa ;

Pasqualetti, Patrizio ;

Robitaille, Nicolas ;

Duchesne, Simon ;

Jack, Clifford R., Jr. ;

Frisoni, Giovanni B. .

ALZHEIMERS & DEMENTIA, 2015, 11 (02) :151-160

[4] The use of biomarkers for the etiologic diagnosis of MCI in Europe: An EADC survey [J].

Bocchetta, Martina ;

Galluzzi, Samantha ;

Kehoe, Patrick Gavin ;

Aguera, Eduardo ;

Bernabei, Roberto ;

Bullock, Roger ;

Ceccaldi, Mathieu ;

Dartigues, Jean-Francois ;

de Mendonca, Alexandre ;

Didic, Mira ;

Eriksdotter, Maria ;

Felician, Olivier ;

Froelich, Lutz ;

Gertz, Hermann-Josef ;

Hallikainen, Merja ;

Hasselbalch, Steen G. ;

Hausner, Lucrezia ;

Heuser, Isabell ;

Jessen, Frank ;

Jones, Roy W. ;

Kurz, Alexander ;

Lawlor, Brian ;

Lleo, Alberto ;

Martinez-Lage, Pablo ;

Mecocci, Patrizia ;

Mehrabian, Shima ;

Monsch, Andreas ;

Nobili, Flavio ;

Nordberg, Agneta ;

Rikkert, Marcel Olde ;

Orgogozo, Jean-Marc ;

Pasquier, Florence ;

Peters, Oliver ;

Salmon, Eric ;

Sanchez-Castellano, Carmen ;

Santana, Isabel ;

Sarazin, Marie ;

Traykov, Latchezar ;

Tsolaki, Magda ;

Visser, Pieter Jelle ;

Wallin, Asa K. ;

Wilcock, Gordon ;

Wilkinson, David ;

Wolf, Henrike ;

Yener, Goersev ;

Zekry, Dina ;

Frisoni, Giovanni B. .

ALZHEIMERS & DEMENTIA, 2015, 11 (02) :195-206

[5] Beta regression models: Joint mean and variance modeling [J].

Cepeda-Cuervo E. .

Journal of Statistical Theory and Practice, 2015, 9 (1) :134-145

[6] Integrating longitudinal information in hippocampal volume measurements for the early detection of Alzheimer's disease [J].

Chincarini, Andrea ;

Sensi, Francesco ;

Rei, Luca ;

Gemme, Gianluca ;

Squarcia, Sandro ;

Longo, Renata ;

Brun, Francesco ;

Tangaro, Sabina ;

Bellotti, Roberto ;

Amorosoc, Nicola ;

Bocchetta, Martina ;

Redolfi, Alberto ;

Bosco, Paolo ;

Boccardi, Marina ;

Frisoni, Giovanni B. ;

Nobili, Flavio .

NEUROIMAGE, 2016, 125 :834-847

[7] Combination of 18F-FDG PET and Cerebrospinal Fluid Biomarkers as a Better Predictor of the Progression to Alzheimer's Disease in Mild Cognitive Impairment Patients [J].

Choo, Il Han ;

Ni, Ruiqing ;

Scholl, Michael ;

Wall, Anders ;

Almkvist, Ove ;

Nordberg, Agneta .

JOURNAL OF ALZHEIMERS DISEASE, 2013, 33 (04) :929-939

[8] Towards accurate, automatic segmentation of the hippocampus and amygdala from MRI by augmenting ANIMAL with a template library and label fusion [J].

Collins, D. Louis ;

Pruessner, Jens C. .

NEUROIMAGE, 2010, 52 (04) :1355-1366

[9] Research criteria for the diagnosis of Alzheimer"s disease: revising the NINCDS-ADRDA criteria [J].

Dubois, Bruno ;

Feldman, Howard H. ;

Jacova, Claudia ;

Dekosky, Steven T. ;

Barberger-Gateau, Pascale ;

Cummings, Jeffrey ;

Delocourte, Andre ;

Galasko, Douglas ;

Gauthier, Serge ;

Jicha, Gregory ;

Meguro, Kenichi ;

O'Brien, John ;

Pasquier, Florence ;

Robert, Philippe ;

Rossor, Martin ;

Solloway, Steven ;

Stern, Yaakov ;

Visser, Pieter J. ;

Scheltens, Philip .

LANCET NEUROLOGY, 2007, 6 (08) :734-746

[10] Revising the definition of Alzheimer's disease: a new lexicon [J].

Dubois, Bruno ;

Feldman, Howard H. ;

Jacova, Claudia ;

Cummings, Jeffrey L. ;

DeKosky, Steven T. ;

Barberger-Gateau, Pascale ;

Delacourte, Andre ;

Frisoni, Giovanni ;

Fox, Nick C. ;

Galasko, Douglas ;

Gauthier, Serge ;

Hampel, Harald ;

Jicha, Gregory A. ;

Meguro, Kenichi ;

O'Brien, John ;

Pasquier, Florence ;

Robert, Philippe ;

Rossor, Martin ;

Salloway, Steven ;

Sarazin, Marie ;

de Souza, Leonardo C. ;

Stern, Yaakov ;

Visser, Pieter J. ;

Scheltens, Philip .

LANCET NEUROLOGY, 2010, 9 (11) :1118-1127

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