The molecular physiology of liver regeneration following partial hepatectomy

被引:132
|
作者
Mangnall, D [1 ]
Bird, NC [1 ]
Majeed, AW [1 ]
机构
[1] Royal Hallamshire Hosp, Dept Surg & Anaesthet Sci, Sheffield S10 2JF, S Yorkshire, England
关键词
liver; regeneration; cell cycle; extracellular matrix; cytokines; growth factors;
D O I
10.1034/j.1600-0676.2003.00812.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The ability of the liver to regenerate after resection has been known for many years. Two reports from Germany in the late 1800s probably mark the introduction of the phenomenon into the scientific literature, but in the early 1900s the first reviews of this subject had appeared in the English literature. Predating these early scientific reports the legends from the Greek mythology described the fate of Prometheus. As punishment for defying Zeus and revealing the secret of fire to man, Prometheus was chained to a rock and each day had part of his liver ripped out by an eagle which, returning the following day, repeated the torture because his liver regenerated itself overnight. Although the speed of regeneration in the Greek legend is somewhat greater than that observed either clinically or in the laboratory, the myth does serve to emphasise the remarkable ability of the liver to repeatedly regenerate following repeated resections. This review aims to summarise the more recent literature concerning the early molecular events accompanying liver regeneration and to integrate this with the existing knowledge of this subject.
引用
收藏
页码:124 / 138
页数:15
相关论文
共 50 条
  • [21] Tissue injury of the remnant liver following radiofrequency-assisted partial hepatectomy
    Ypsilantis, Petros
    Lambropoulou, Maria
    Karayiannakis, Anastasios
    Milicevic, Miroslav
    Bulajic, Predrag
    Zacharoulis, Dimitrios
    Sioka, Eleni
    Simopoulos, Constantinos
    JOURNAL OF BUON, 2017, 22 (05): : 1172 - 1179
  • [22] Liver Regeneration after Partial Hepatectomy Critical Analysis of Mechanistic Dilemmas
    Michalopoulos, George K.
    AMERICAN JOURNAL OF PATHOLOGY, 2010, 176 (01) : 2 - 13
  • [23] DOES ADJUVANT RADIOTHERAPY SUPPRESS LIVER REGENERATION AFTER PARTIAL HEPATECTOMY?
    Choi, Jin-Hwa
    Kim, Kyubo
    Chie, Eui Kyu
    Jang, Jin-Young
    Kim, Sun Whe
    Oh, Do-Youn
    Im, Seock-Ah
    Kim, Tae-You
    Bang, Yung-Jue
    Ha, Sung W.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2009, 74 (01): : 67 - 72
  • [24] Decorin accelerates the liver regeneration after partial hepatectomy in fibrotic mice
    Ma Rui
    Chen Jiang
    Li Zheyong
    Tang Jiacheng
    Wang Yifan
    Cai Xiujun
    CHINESE MEDICAL JOURNAL, 2014, 127 (14) : 2679 - 2685
  • [25] Effects of cyclosporin and somatostatin on liver regeneration after partial hepatectomy in rats
    Kapan, M
    Ipek, T
    Sad, A
    Goksel, S
    Sirin, F
    EUROPEAN SURGICAL RESEARCH, 1996, 28 (04) : 262 - 269
  • [26] Deficiency of periostin impairs liver regeneration in mice after partial hepatectomy
    Wu, Tiantian
    Huang, Jingwen
    Wu, Shasha
    Huang, Zhengjie
    Chen, Xiaoyan
    Liu, Yingfu
    Cui, Dan
    Song, Gang
    Luo, Qi
    Liu, Fan
    Ouyang, Gaoliang
    MATRIX BIOLOGY, 2018, 66 : 81 - 92
  • [27] MRI as Primary End Point for Pharmacologic Experiments of Liver Regeneration in a Murine Model of Partial Hepatectomy
    Orsini, Vanessa
    Zurbruegg, Stefan
    Pikiolek, Monika
    Tchorz, Jan S.
    Beckmann, Nicolau
    ACADEMIC RADIOLOGY, 2016, 23 (11) : 1446 - 1453
  • [28] Increased growth of colorectal liver metastasis following partial hepatectomy
    Krause, P.
    Flikweert, H.
    Monin, M.
    Hosseini, A. Seif Amir
    Helms, G.
    Cantanhede, G.
    Ghadimi, B. M.
    Koenig, S.
    CLINICAL & EXPERIMENTAL METASTASIS, 2013, 30 (05) : 681 - 693
  • [29] Changes in the expression of cell cycle regulators during rat liver regeneration after partial hepatectomy
    Cho, H
    Lim, IK
    Lee, JH
    EXPERIMENTAL AND MOLECULAR MEDICINE, 1996, 28 (04) : 187 - 191
  • [30] Mild hypothermia does not affect liver regeneration after partial hepatectomy in mice
    Pablo Arab, Juan
    Pizarro, Margarita
    Solis, Nancy
    Sun, Hongdan
    Thevananther, Sundararajah
    Arrese, Marco
    LIVER INTERNATIONAL, 2009, 29 (03) : 344 - 348