PEG10 as an oncogene: expression regulatory mechanisms and role in tumor progression

被引：55

作者：

Xie, Tian ^{[1
]}

Pan, Shan ^{[1
]}

Zheng, Hang ^{[2
]}

Luo, Zilv ^{[1
]}

Tembo, Kingsley M. ^{[3
]}

Jamal, Muhammad ^{[4
]}

Yu, Zhongyang ^{[1
]}

Yu, Yao ^{[1
]}

Xia, Jing ^{[1
]}

Yin, Qian ^{[1
]}

Wang, Meng ^{[1
]}

Yuan, Wen ^{[1
]}

Zhang, Qiuping ^{[1
,5
]}

Xiong, Jie ^{[1
]}

机构：

[1] Wuhan Univ, Sch Basic Med Sci, Dept Immunol, Wuhan 430071, Peoples R China

[2] Wuhan Univ, Zhongnan Hosp, Dept Urol, Wuhan 430071, Peoples R China

[3] Michael Chilufya Sata Hosp, Mpika, Zambia

[4] Huazhong Agr Univ, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China

[5] Wuhan Univ, Hubei Prov Key Lab Dev Originated Dis, Wuhan 430071, Peoples R China

来源：

CANCER CELL INTERNATIONAL | 2018年 / 18卷

基金：

中国国家自然科学基金;

关键词：

PEG10; Regulatory mechanisms; Proliferation; Apoptosis; Metastasis; Targeted therapies; GENE-EXPRESSION; IMPRINTED GENE; HEPATOCELLULAR-CARCINOMA; CANCER-IMMUNOTHERAPY; PROBABLE TARGET; MAMMALIAN GENE; CRUCIAL ROLE; C-MYC; IDENTIFICATION; RETROTRANSPOSON;

D O I：

10.1186/s12935-018-0610-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer is a major public health problem as one of the leading causes of death worldwide. Deciphering the molecular regulation mechanisms of tumor progression can make way for tumor diagnosis and therapy. Paternally expressed gene 10 (PEG10), located on human chromosome 7q21.3, has turned out to be an oncogene implicated in the proliferation, apoptosis and metastasis of tumors. PEG10 has been found to be positively expressed in a variety of cancers with seemingly complex expression regulation mechanisms. In this review, we focus on the most vital factors influencing PEG10 expression and recapitulate some of the currently known and potential mechanisms of PEG10 affecting tumor progression, as understanding the molecular regulatory mechanisms of tumor progression can provide potential PEG10 related diagnosis and biomarker specific targeted therapies.

引用

页数：10

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