The met receptor tyrosine kinase and basal breast cancer

被引:29
作者
Ponzo, Marisa G. [1 ,2 ]
Park, Morag [1 ,2 ,3 ,4 ]
机构
[1] McGill Univ, Rosalind & Morris Goodman Canc Ctr, Montreal, PQ, Canada
[2] McGill Univ, Dept Expt Med, Montreal, PQ, Canada
[3] McGill Univ, Dept Oncol, Montreal, PQ, Canada
[4] McGill Univ, Dept Biochem, Montreal, PQ, Canada
关键词
transgenic mouse model; basal breast cancer; gene expression profiling; met receptor tyrosine kinase; epithelial to mesenchymal transition; HEPATOCYTE GROWTH-FACTOR; CELL LUNG-CANCER; MESENCHYMAL STEM-CELLS; FACTOR SCATTER FACTOR; GENE COPY NUMBER; C-MET; MAMMARY TUMORIGENESIS; MOUSE MODEL; PROMOTER METHYLATION; MUTATIONAL ANALYSIS;
D O I
10.4161/cc.9.6.11033
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Breast cancer is a complex disease that comprises cancers of distinct biologies and responses to treatment. Clinical management relies on traditional clinicopathological parameters, involving lymph node status, histological grade, as well as expression of the estrogen receptor or human epidermal growth factor receptor 2. Molecular pathology as well as protein and gene expression profiling have divided breast tumors into molecular subtypes associated with different clinical outcomes. One of these, defined as basal breast cancer, is associated with poor prognosis. Molecular mechanisms involved in the induction of basal breast cancer are poorly understood and targeted therapies for this subtype are lacking. Recent evidence using murine models identified a role for the Met receptor tyrosine kinase in the induction of murine mammary tumors with characteristics of human basal breast cancers. Moreover, elevated Met protein and RNA is associated with human basal tumors and poor outcome. These studies identify a link between the Met receptor tyrosine kinase, epithelial mesenchymal transition, and basal breast cancer. In this review, we provide an overview of murine Met models in relation to the spectrum of mouse models of breast cancer and a role for the Met receptor in basal breast cancer tumorigenesis.
引用
收藏
页码:1043 / 1050
页数:8
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