What is MRI bone oedema in rheumatoid arthritis and why does it matter?

被引：97
作者：
McQueen, Fiona M.
Ostendorf, Benedikt
机构：
[1] Univ Auckland, Dept Mol Med & Pathol, Fac Med & Hlth Sci, Auckland 1, New Zealand
[2] Univ Dusseldorf, Ctr Rheumatol, Dept Endocrinol Diabetol & Rheumatol, D-4000 Dusseldorf, Germany
来源：
ARTHRITIS RESEARCH & THERAPY | 2006年 / 8卷 / 06期
关键词：
D O I：
10.1186/ar2075
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
MRI bone oedema occurs in various forms of inflammatory and noninflammatory arthritis and probably represents a cellular infiltrate within bone. It is common in early rheumatoid arthritis and is associated with erosive progression and poor functional outcome. Histopathological studies suggest that a cellular infiltrate comprising lymphocytes and osteoclasts may be detected in subchondral bone and could mediate the development of erosions from the marrow towards the joint surface. There is emerging evidence from animal models that such an infiltrate corresponds with MRI bone oedema, pointing towards the bone marrow as a site for important pathology driving joint damage in rheumatoid arthritis.
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