Gynostemosides A-E, megastigmane glycosides from Gynostemma pentaphyllum

被引：75

作者：

Zhang, Zhen ^{[1
,2
]}

Zhang, Wei ^{[3
]}

Ji, Yan-Ping ^{[1
,2
]}

Zhao, Yun ^{[1
,2
]}

Wang, Chuan-Gui ^{[3
]}

Hu, Jin-Feng ^{[1
,2
]}

机构：

[1] E China Normal Univ, Dept Nat Prod Chem Genet Res, Key Lab Brain Funct Genom, Minist Educ, Shanghai 200062, Peoples R China

[2] E China Normal Univ, Shanghai Key Lab Brain Funct Genom MOE&SBFG, Shanghai 200062, Peoples R China

[3] E China Normal Univ, Sch Life Sci, Inst Biomed Sci, Shanghai 200241, Peoples R China

来源：

PHYTOCHEMISTRY | 2010年 / 71卷 / 5-6期

关键词：

Gynostemma pentaphyllum; Cucurbitaceae; Megastigmane glycosides; Absolute configuration; BETA-IONONE; ABSCISIC-ACID; APOLLONIAS-BARBUJANA; CANCER CELLS; LEAVES; GLUCOSIDES; SAPONINS; C-13-NORISOPRENOIDS; CHEMOPREVENTION; PROLIFERATION;

D O I：

10.1016/j.phytochem.2009.12.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Megastigmane glycosides (1-5) together with seven (6-12) related known compounds were isolated from the whole plants of Gynostemma pentaphyllum. The structures were elucidated by means of spectroscopic methods, including 2D NMR, HR-ESIMS, and circular dichroism (CD), as well as chemical transformations to be (3R, 4R, 5S, 6S, 7E)-3,4,6-trihydroxymegastigmane-7-en-9-one-3-O-beta-D-glucopyranoside (gynostemoside A. 1), (3S, 4S, 5R, 6R, 7E, 9R)-3,4,6,9-tetrahydroxymegastigmane-7-en-3-O-beta-D-glucopyranoside (gynostemoside B, 2), (3S, 4S, 5S, 6S, 7E, 9R)-3,4,9-trihydroxymegastigmane-7-en-9-O-beta-D-glucopyranoside (gynostemoside C, 3), (3S, 4S, 5S, 6S, 7E, 9R)-3,4,9-trihydroxymegastigmane-7-en-3-O-beta-D-glucopyranoside (gynostemoside D, 4), and (3S, 4S, 5S, 6S, 7E, 9R)-3,4,9-trihydroxymegastigmane-7-en-4-O-beta-D-glucopyranoside (gynostemoside E, 5), respectively. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：693 / 700

页数：8

共 40 条

[1] β-carotene breakdown products enhance genotoxic effects of oxidative stress in primary rat hepatocytes [J].