Synthesis and cytotoxic activity of new heterocyclic analogues of resveratrol, containing benzoxazolone ring

被引：0

作者：

Gerova, M. S. ^{[1
]}

Aleksandrova, E. A. ^{[1
,2
]}

Ivanova, Y. B. ^{[3
]}

Stanisheva, D. V. ^{[1
]}

Momekov, G. Ts. ^{[4
]}

Petrov, O. I. ^{[1
]}

机构：

[1] Sofia Univ St Kliment Ohridski, Fac Chem & Pharm, Dept Pharmaceut & Appl Organ Chem, 1 James Bourchier Blvd, Sofia 1164, Bulgaria

[2] Trakia Univ, Med Fac, Dept Gen & Clin Pathol, 11 Armeiska Str, Stara Zagora 6000, Bulgaria

[3] Univ Forestry, Fac Ecol & Landscape Architecture, Dept Plant Pathol & Chem, 10 Kliment Ohridsky Blvd, Sofia 1756, Bulgaria

[4] Med Univ Sofia, Fac Pharm, Dept Pharmacol Pharmacotherapy & Toxicol, 2 Dunav Str, Sofia 1000, Bulgaria

来源：

BULGARIAN CHEMICAL COMMUNICATIONS | 2017年 / 49卷

关键词：

resveratrol; benzoxazolone; stilbene; cytotoxicity; BIOLOGICAL EVALUATION; CANCER; AGENTS; PREVENTION; SCAFFOLD;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New heterocycle analogues of resveratrol were designed and synthesized as potential anticancer agents. The compounds contain 3,5-dimethoxy-or 3,5-dihydroxystyryl fragment attached to the C5 or C6 position of a benzoxazolone ring. The compounds were tested for their cytotoxic activity against three human cancer cell lines (HL60, MGF-7 and MDA-MB-321) and some of them were found to exhibit significant antiproliferative effect. Generally, the obtained 5-styrylbenzoxazolones were more active in compare to the corresponding 6-styrylbenzoxazolone positional isomers.

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页码：71 / 75

页数：5

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