Comparative genomic hybridization analysis suggests a gain of chromosome 7p associated with lymph node metastasis in non-small cell lung cancer

被引：0
作者：
Ubagai, T
Matsuura, S
Tauchi, H
Itou, K
Komatsu, K
机构：
[1] Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Radiat Biol, Minami Ku, Hiroshima 7348553, Japan
[2] Hiroshima Univ, Sch Med, Dept Radiol, Minami Ku, Hiroshima 7348553, Japan
来源：
ONCOLOGY REPORTS | 2001年 / 8卷 / 01期
关键词：
comparative genomic hybridization; non-small cell lung cancer; lymph node metastasis; metastasis-associated gene; gain of chromosome 7p;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We analyzed the chromosomal gains and losses that occur in 30 non-small cell lung carcinomas by comparative genomic hybridization. Their chromosomal imbalances showed histological type-specific patterns in adenocarcinomas and in squamous cell carcinomas. The genetic changes in non-small cell lung carcinoma were also strongly dependent on metastasis to lymph node. The average numbers of chromosomal alterations were increased from 6.2 to 9.1 along with the presence of metastasis, and it gave rise to the increased copy number in specific chromosomes. In particular, a novel imbalance at 7p12-21 was recognized in a half of carcinoma with metastasis, although no genetic alteration was observed in 15 non-metastasizing lung carcinoma tested here.
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收藏
页码：83 / 88
页数：6
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