Bis-Suzuki reactions of 2,3-dihaloindoles. A convenient synthesis of 2,3-diarylindoles

被引：63

作者：

Liu, YB ^{[1
]}

Gribble, GW ^{[1
]}

机构：

[1] Dartmouth Coll, Dept Chem, Hanover, NH 03755 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 45期

基金：

美国国家卫生研究院;

关键词：

Suzuki reaction; palladium-catalyzed cross coupling; 2,3-diarylindoles; indoxole;

D O I：

10.1016/S0040-4039(00)01564-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient, one-pot synthesis of 2,3-diarylindoles 4 is described via a bis-Suzuki palladium-catalyzed cross coupling of 2,3-dihalo-1-(phenylsulfonyl)indoles 1 with arylboronic acids 2, followed by cleavage of the N-protecting group to give 4. The anti-inflammatory drug indoxole (4c) is prepared in high yield. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

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页码：8717 / 8721

页数：5

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