Efflux Pumps Are Involved in the Defense of Gram-Negative Bacteria against the Natural Products Isobavachalcone and Diospyrone

被引：82
作者：
Kuete, Victor [2 ]
Ngameni, Bathelemy [3 ]
Tangmouo, Jean G. [4 ]
Bolla, Jean-Michel
Alibert-Franco, Sandrine
Ngadjui, Bonaventure T. [3 ,4 ]
Pages, Jean-Marie [1 ]
机构：
[1] Univ Aix Marseille 2, IFR 88, Fac Med & Pharm, UFR Med,UMR MD1, F-13385 Marseille 05, France
[2] Univ Dschang, Fac Sci, Dept Biochem, Dschang, Cameroon
[3] Univ Yaounde 1, Fac Med & Biomed Sci, Dept Pharm & Tradit Pharmacopoeia, Yaounde, Cameroon
[4] Univ Yaounde 1, Fac Sci, Dept Organ Chem, Yaounde, Cameroon
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 05期
关键词：
ESCHERICHIA-COLI; ENTEROBACTER-AEROGENES; PSEUDOMONAS-AERUGINOSA; ANTIMICROBIAL ACTIVITY; ANTIBIOTIC-RESISTANCE; MULTIDRUG-RESISTANCE; DRUG-RESISTANCE; SUSCEPTIBILITY; EXPRESSION; STRATEGIES;
D O I：
10.1128/AAC.01533-09
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The activities of two naturally occurring compounds, isobavachalcone and diospyrone, against documented strains and multidrug-resistant (MDR) Gram-negative bacterial isolates were evaluated. The results indicated that the two compounds exhibited intrinsic antibacterial activity against several Gram-negative bacteria, and their activities were significantly improved in the presence of an efflux pump inhibitor (MIC values decreased to below 10 mu g/ml). In addition, the activities of isobavachalcone and diospyrone against various strains exhibiting deletions of the major efflux pump components (AcrAB, TolC) were significantly increased. The overall results indicate that isobavachalcone and diospyrone could be candidates for the development of new drugs against MDR strains and that their use in combination with efflux pump inhibitors reinforces their activity.
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收藏
页码：1749 / 1752
页数：4
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