Adverse lipid and coronary heart disease risk profiles in young women with polycystic ovary syndrome: Results of a case-control study

被引:226
作者
Talbott, E
Clerici, A
Berga, SL
Kuller, L
Guzick, D
Detre, K
Daniels, T
Engberg, RA
机构
[1] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15261 USA
[2] Univ Pittsburgh, Magee Womens Hosp, Sch Med, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA 15213 USA
关键词
lipids; PCOS; case-control study; estradiol; women; heart disease;
D O I
10.1016/S0895-4356(98)00010-9
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Polycystic ovary syndrome (PCOS), a disorder of hyperandrogenism and chronic anovulation affects 5%-10% of all women. Women with PCOS often have elevated cardiovascular risk factors. A total of 244 PCOS cases were identified through the Division of Reproductive Endocrinology at Magee-Womens Hospital and were age-matched to 244 neighborhood controls. The average age of cases and controls was 35.3 +/- 7.4 and 36.7 +/- 7.7. Women with PCOS compared to controls had substantially higher LDL-C and total cholesterol levels at each age group under 45 years after adjustment for body mass index, hormone use, and insulin levels. In the over 40-year age group, Little difference was noted between cases and controls. Among cases and controls (<40), PCOS predicted LDL-C, total cholesterol and triglycerides, but did not have a significant effect on lipid levels in older cases and controls after controlling for the other variables. The primarily pre- to perimenopausal PCOS cases greater than or equal to 40 years of age have similar LDL-C and total cholesterol levels as their age-matched controls, probably reflecting the LDL-C increase with age among controls. (C) 1998 Elsevier Science Inc.
引用
收藏
页码:415 / 422
页数:8
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