Spastic diplegia as a complication of interferon Alfa-2a treatment of hemangiomas of infancy

被引：289

作者：

Barlow, CF

Priebe, CJ

Mulliken, JB

Barnes, PD

Mac Donald, D

Folkman, J

Ezekowitz, RAB ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Serv Pediat, Boston, MA 02114 USA

[2] Childrens Hosp, Dept Neurol, Div Plast Surg, Boston, MA 02115 USA

[3] Childrens Hosp, Dept Med, Div Plast Surg, Boston, MA 02115 USA

[4] Childrens Hosp, Dept Surg, Div Plast Surg, Boston, MA 02115 USA

[5] Childrens Hosp, Dept Radiol, Div Plast Surg, Boston, MA 02115 USA

[6] Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA

[7] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA

[8] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA

来源：

JOURNAL OF PEDIATRICS | 1998年 / 132卷 / 03期

关键词：

D O I：

10.1016/S0022-3476(98)70034-4

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We report the development of spastic diplegia in infants during the course of in terferon Alfa-2a (IFN) therapy for potentially life-endangering hemangiomas. Five infants who displayed diplegia were selected from a group of 26 infants treated with IFN. Diplegia persisted in three infants, and in the remaining two signifcant recovery occurred after IFN was discontinued. Magnetic resonance imaging showed no significant brain or spinal abnormalities except minor to moderate delayed myelination in two patients. Myelination was normal on subsequent radiographic examination in all five patients. We conclude that IFN can adversely affect the immature central nervous system and produce spastic diplegia, which is potentially reversible. We recommend careful clinical assessment of neurodevelopmental status during IFN therapy.

引用

页码：527 / 530

页数：4

共 13 条

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