Phase separation and histone epigenetics in genome regulation

被引：9

作者：

Harrison, Reed E. S. ^{[1
,2
]}

Weng, Kegui ^{[1
,2
,3
,4
,5
]}

Wang, Yingxiao ^{[1
,2
]}

Peng, Qin ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Inst Engn Med, La Jolla, CA 92093 USA

[3] Chongqing Univ, Canc Hosp, Chongqing 400044, Peoples R China

[4] Chongqing Canc Inst, Chongqing 400044, Peoples R China

[5] Chongqing Canc Hosp, Chongqing 400044, Peoples R China

来源：

CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE | 2021年 / 25卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Phase separation; Histone epigenetics; Chromatin; Genome regulation; CHROMATIN MODIFICATIONS; METHYLATION; HETEROCHROMATIN; PHOSPHORYLATION; ACETYLATION; LANDSCAPE; LYSINE-4; DISTINCT; BINDING; H3;

D O I：

10.1016/j.cossms.2020.100892

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Liquid-liquid phase separation is increasingly recognized as a phenomenon that affects cell behavior. For example, phase separation of transcription factors and coactivators has been shown to drive efficient transcription. For many years, phase separation of intracellular components has been observed; however, only recently have researchers been able to garner functional significance from such events. Inspired from recent literature that describes phase separation of chromatin in a histone-dependent manner, we review the role and effect of phase separation and histone epigenetics in regulating the genome and discuss how these phenomena can be leveraged to control cell behavior.

引用

页数：9

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