Synthesis and Antioxidant Capacity of Some Derivatives of Sesamol at the C-6 Position

被引：7
作者：
Buravlev, Evgeny V. [1 ]
Shevchenko, Oksana G. [2 ]
Suponitsky, Kyrill Yu. [3 ]
机构：
[1] Russian Acad Sci, Ural Branch, Komi Sci Ctr, Inst Chem, 48,Pervomayskaya St, Syktyvkar 167000, Komi Republic, Russia
[2] Russian Acad Sci, Ural Branch, Komi Sci Ctr, Inst Biol, 28,Kommunist Skaya St, Syktyvkar 167982, Komi Republic, Russia
[3] Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, 28,Vavilova St, Moscow 119991, Russia
来源：
CHEMISTRY & BIODIVERSITY | 2021年 / 18卷 / 06期
关键词：
Mannich bases; alkylation; antioxidant activity; oxidative hemolysis; synthesis; BUTYLATED HYDROXYTOLUENE BHT; IN-VITRO; MANNICH-BASES; DIARYLMETHYLAMINES; PREVENTION; XANTHONES; CHEMISTRY; AMINES; OIL;
D O I：
10.1002/cbdv.202100221
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Several synthetic approaches (aminomethylation, alkylation, condensation, etc.) have been used to synthesize derivatives based on the sesamol (1), natural phenol. The set of methods, including the study of antioxidant activity (AOA) by the ability to inhibit the initiated oxidation of animal lipids, radical scavenging activity, Fe2+-chelation ability, as well as a comparative assessment of membrane-protective activity under the conditions of H2O2-induced hemolysis of mice red blood cells (RBCs), was used to analyze the antioxidant potential of the synthesized compounds. The synthesized derivatives have demonstrated different activity in the listed test systems, and we have identified compounds which appear to be most promising for a detailed study of their pharmacological properties.
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页数：11
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