Cytoglobosins A-G, Cytochalasans from a Marine-Derived Endophytic Fungus, Chaetomium globosum QEN-14

被引：123

作者：

Cui, Chuan-Ming ^{[1
,2
]}

Li, Xiao-Ming ^{[1
]}

Li, Chun-Shun ^{[1
]}

Proksch, Peter ^{[3
]}

Wang, Bin-Gui ^{[1
]}

机构：

[1] Chinese Acad Sci, Key Lab Expt Marine Biol, Inst Oceanol, Qingdao 266071, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

[3] Univ Dusseldorf, Inst Pharmazeut Biol & Biotechnol, D-40225 Dusseldorf, Germany

来源：

JOURNAL OF NATURAL PRODUCTS | 2010年 / 73卷 / 04期

基金：

美国国家科学基金会;

关键词：

ASPERGILLUS-NIGER EN-13; CHAETOGLOBOSINS; ALGA; METABOLITES;

D O I：

10.1021/np900569t

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Cytoglobosins A-G (1-7), seven new cytochalasan derivatives, along with two structurally related known compounds, isochaetoglobosin D (8) and chaetoglobosin F(ex) (9), were isolated and identified from the cultures of Chaetomium globosum QEN-14, an endophytic fungus derived from the marine green alga Ulva pertusa. The structures of the new natural products as well as their relative configurations were elucidated on the basis of 1D and 2D NMR spectra (COSY, HSQC, HMBC, and NOESY) and HRESIMS data. Cytoglobosins C and D (3 and 4) displayed cytotoxic activity against the A-549 tumor cell line.

引用

页码：729 / 733

页数：5

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