Loss of Response to Anti-TNFs: Definition, Epidemiology, and Management

被引：541

作者：

Roda, Giulia ^{[1
]}

Jharap, Bindia ^{[2
]}

Neeraj, Narula ^{[1
]}

Colombel, Jean-Frederic ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, Henry D Janowitz Div Gastroenterol, Leona M Harry B Helmsley Inflammatory Bowel Dis C, One Gustave Levy Pl, New York, NY 10029 USA

[2] Meander Med Ctr, Amersfoort, Netherlands

来源：

CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY | 2016年 / 7卷

关键词：

TUMOR-NECROSIS-FACTOR; INFLAMMATORY-BOWEL-DISEASE; SCHEDULED INFLIXIMAB MAINTENANCE; CROHNS-DISEASE; DOSE INTENSIFICATION; CLINICAL-RESPONSE; ADALIMUMAB; THERAPY; EFFICACY; DRUG;

D O I：

10.1038/ctg.2015.63

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Tumor necrosis factor-alpha (TNF alpha) antagonists have advanced the management of inflammatory bowel diseases patients leading to an improvement of patient's quality of life with the reduction of number of surgeries and hospitalizations. Despite these advances, many patients do not respond to the induction therapy (primary non-response-PNR) or lose response during the treatment (secondary loss of response-LOR). In this paper we will provide an overview of the definition, epidemiology and risk factors for PNR and LOR, as well as discuss the therapeutic options for managing LOR.

引用

页数：5

共 56 条

[1] Association Between Serum Concentration of Infliximab and Efficacy in Adult Patients With Ulcerative Colitis [J].

Adedokun, Omoniyi J. ;

Sandborn, William J. ;

Feagan, Brian G. ;

Rutgeerts, Paul ;

Xu, Zhenhua ;

Marano, Colleen W. ;

Johanns, Jewel ;

Zhou, Honghui ;

Davis, Hugh M. ;

Cornillie, Freddy ;

Reinisch, Walter .

GASTROENTEROLOGY, 2014, 147 (06) :1296-+

[2] Clinical Utility of Measuring Infliximab and Human Anti-Chimeric Antibody Concentrations in Patients With Inflammatory Bowel Disease [J].

Afif, Waqqas ;

Loftus, Edward V., Jr. ;

Faubion, William A. ;

Kane, Sunanda V. ;

Bruining, David H. ;

Hanson, Karen A. ;

Sandborn, William J. .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2010, 105 (05) :1133-1139

[3] Tumor necrosis factor-alpha binding capacity and anti-infliximab antibodies measured by fluid-phase radioimmunoassays as predictors of clinical efficacy of infliximab in Crohn's disease [J].

Ainsworth, Mark A. ;

Bendtzen, Klaus ;

Brynskov, Jorn .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2008, 103 (04) :944-948

[4] Report of the ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases: Definitions, frequency and pharmacological aspects [J].

Allez, Matthieu ;

Karmiris, Konstantinos ;

Louis, Edouard ;

Van Assche, Gert ;

Ben-Horin, Shomron ;

Klein, Amir ;

Van der Woude, Janneke ;

Baert, Filip ;

Eliakim, Rami ;

Katsanos, Konstantinos ;

Brynskov, Jorn ;

Steinwurz, Flavio ;

Danese, Silvio ;

Vermeire, Severine ;

Teillaud, Jean-Luc ;

Lemann, Marc ;

Chowers, Yehuda .

JOURNAL OF CROHNS & COLITIS, 2010, 4 (04) :355-366

[5] Dose optimization of infliximab in patients with rheumatoid arthritis [J].

Alten, Rieke ;

van den Bosch, Filip .

INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, 2014, 17 (01) :5-18

[6] Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease [J].

Baert, F ;

Noman, M ;

Vermeire, S ;

Van Assche, G ;

D'Haens, G ;

Carbonez, A ;

Rutgeerts, P .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (07) :601-608

[7] Review article: loss of response to anti-TNF treatments in Crohn's disease [J].

Ben-Horin, S. ;

Chowers, Y. .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2011, 33 (09) :987-995

[8] Loss of Response to Anti-Tumor Necrosis Factors: What Is the Next Step? [J].

Ben-Horin, Shomron .

DIGESTIVE DISEASES, 2014, 32 (04) :384-388

[9] Optimizing anti-TNF treatments in inflammatory bowel disease [J].

Ben-Horin, Shomron ;

Kopylov, Uri ;

Chowers, Yehuda .

AUTOIMMUNITY REVIEWS, 2014, 13 (01) :24-30

[10] Addition of an Immunomodulator to Infliximab Therapy Eliminates Antidrug Antibodies in Serum and Restores Clinical Response of Patients With Inflammatory Bowel Disease [J].

Ben-Horin, Shomron ;

Waterman, Matti ;

Kopylov, Uri ;

Yavzori, Miri ;

Picard, Orit ;

Fudim, Ella ;

Awadie, Halim ;

Weiss, Batia ;

Chowers, Yehuda .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2013, 11 (04) :444-447

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