Dual Optical Signal-based Intraocular Pressure-sensing Principle Using Pressure-sensitive Mechanoluminescent ZnS:Cu/PDMS Soft Composite

被引:14
作者
Kim, Yooil [2 ]
Roy, Sunanda [1 ]
Jung, Gwang-Yong [1 ]
Oh, Jung-Sik [2 ]
Kim, Gi-Woo [1 ]
机构
[1] Inha Univ, Dept Mech Engn, Incheon 22212, South Korea
[2] Inha Univ, Dept Naval Architecture & Ocean Engn, Incheon 22212, South Korea
基金
新加坡国家研究基金会;
关键词
NON-CONTACT TONOMETER; GLAUCOMA; EYES;
D O I
10.1038/s41598-019-51771-z
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
This paper presents a novel principle for intraocular pressure (IOP)-sensing (monitoring) based on a pressure-sensitive soft composite in which a dual optical signal is produced in response to impulsive pressure input. For the initial assessment of the new IOP sensing principle, a human eye is modeled as the spherically shaped shell structure filled with the pressurized fluid, including cornea, sclera, lens and zonular fiber, and a fluid-structure interaction (FSI) analysis was performed to determine the correlation between the internal pressure and deformation (i.e., strain) rate of the spherical shell structure filled with fluid by formulating the finite element model. The FSI analysis results for human eye model are experimentally validated using a proof-of-conceptual experimental model consisting of a pressurized spherical shell structure filled with fluid and a simple air-puff actuation system. In this study, a mechanoluminescent ZnS:Cu-polydimethylsiloxane (PDMS)-based soft composite is fabricated and used to generate the dual optical signal because mechanically driven ZnS:Cu/PDMS soft composite can emit strong luminescence, suitable for soft sensor applications. Similar to the corneal behavior of the human eye, inward and outward deformations occur on the soft composite attached to the spherical shell structure in response to air puffing, resulting in a dual optical signal in the mechnoluminescence (ML) soft composite.
引用
收藏
页数:10
相关论文
共 30 条
[1]  
Amm M, 2005, OPHTHALMOLOGE, V102, P70, DOI 10.1007/s00347-004-1082-5
[2]   Coupled Biomechanical Response of the Cornea Assessed by Non-Contact Tonometry. A Simulation Study [J].
Ariza-Gracia, Miguel A. ;
Zurita, Jesus F. ;
Pinero, David P. ;
Rodriguez-Matas, Jose F. ;
Calvo, Begona .
PLOS ONE, 2015, 10 (03)
[3]   Assessment of true intraocular pressure: The gap between theory and practical data [J].
Chihara, Etsuo .
SURVEY OF OPHTHALMOLOGY, 2008, 53 (03) :203-218
[4]  
Dassault Systemes, 2019, ABAQUS VER 6 14 REL
[5]   Comparative evaluation of intraocular pressure with an air-puff tonometer versus a Goldmann applanation tonometer [J].
Farhood, Qasim K. .
CLINICAL OPHTHALMOLOGY, 2013, 7 :23-27
[6]  
GOLDMANN H, 1957, Ophthalmologica, V134, P221
[7]  
Groves N, 2006, SHOULD IOP BE ADJUST
[8]   A comprehensive analysis of the Korean fir (Abies koreana) genes expressed under heat stress using transcriptome analysis [J].
Hwang, Jung Eun ;
Kim, Yun Jeong ;
Shin, Myung Hwan ;
Hyun, Hwa Ja ;
Bohnert, Hans J. ;
Park, Hyeong Cheol .
SCIENTIFIC REPORTS, 2018, 8
[9]   Color Manipulation of Mechanoluminescence from Stress-Activated Composite Films [J].
Jeong, Soon Moon ;
Song, Seongkyu ;
Lee, Soo-Keun ;
Ha, Na Young .
ADVANCED MATERIALS, 2013, 25 (43) :6194-6200
[10]   ABC of eyes - Glaucoma - 1: Diagnosis [J].
Khaw, PT ;
Shah, P ;
Elkington, AR .
BRITISH MEDICAL JOURNAL, 2004, 328 (7431) :97-99