Effects of hydrogen sulphide in smooth muscle

被引:38
作者
Dunn, William R. [1 ]
Alexander, Stephen P. H. [1 ]
Ralevic, Vera [1 ]
Roberts, Richard E. [1 ]
机构
[1] Univ Nottingham, Sch Life Sci, Pharmacol Res Grp, Nottingham NG7 2UH, England
关键词
Hydrogen sulphide; Smooth muscle; Vascular; Bronchioles; Gasotransmitter; CYSTATHIONINE GAMMA-LYASE; HYPOXIC PULMONARY VASOCONSTRICTION; K-ATP CHANNELS; HEMORRHAGIC-SHOCK; NITRIC-OXIDE; BETA-SYNTHASE; 3-MERCAPTOPYRUVATE SULFURTRANSFERASE; INDUCED RELAXATION; IN-VITRO; HYPERPOLARIZING FACTOR;
D O I
10.1016/j.pharmthera.2015.12.007
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
In recent years, it has become apparent that the gaseous pollutant, hydrogen sulphide (H2S) can be synthesised in the body and has a multitude of biological actions. This review summarizes some of the actions of this 'gasotransmitter' in influencing the smooth muscle that is responsible for controlling muscular activity of hollow organs. In the vasculature, while H2S can cause vasoconstriction by complex interactions with other biologically important gases, such as nitric oxide, the prevailing response is vasorelaxation. While most vasorelaxation responses occur by a direct action of H2S on smooth muscle cells, it has recently been proposed to be an endothelium-derived hyperpolarizing factor. H2S also promotes relaxation in other smooth muscle preparations including bronchioles, the bladder, gastrointestinal tract and myometrium, opening up the opportunity of exploiting the pharmacology of H2S in the treatment of conditions where smooth muscle tone is excessive. The original concept, that H2S caused smooth muscle relaxation by activating ATP-sensitive K+ channels, has been supplemented with observations that H2S can also modify the activity of other potassium channels, intracellular pH, phosphodiesterase activity and transient receptor potential channels on sensory nerves. While the enzymes responsible for generating endogenous H2S are widely expressed in smooth muscle preparations, it is much less clear what the physiological role of H2S is in determining smooth muscle contractility. Clarification of this requires the development of potent and selective inhibitors of H2S-generating enzymes. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码:101 / 113
页数:13
相关论文
共 169 条
[1]  
Abe K, 1996, J NEUROSCI, V16, P1066
[2]   Hydrogen sulfide treatment reduces blood pressure and oxidative stress in angiotensin II-induced hypertensive mice [J].
Al-Magableh, Mohammad R. ;
Kemp-Harper, Barbara K. ;
Hart, Joanne L. .
HYPERTENSION RESEARCH, 2015, 38 (01) :13-20
[3]   Mechanism of vasorelaxation and role of endogenous hydrogen sulfide production in mouse aorta [J].
Al-Magableh, Mohammad R. ;
Hart, Joanne L. .
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2011, 383 (04) :403-413
[4]   Regulation of vascular nitric oxide in vitro and in vivo; a new role for endogenous hydrogen sulphide? [J].
Ali, M. Y. ;
Ping, C. Y. ;
Mok, Y-Y P. ;
Ling, L. ;
Whiteman, M. ;
Bhatia, M. ;
Moore, P. K. .
BRITISH JOURNAL OF PHARMACOLOGY, 2006, 149 (06) :625-634
[5]  
[Anonymous], BR J PHARM
[6]   Reaction mechanism and regulation of cystathionine β-synthase [J].
Banerjee, R ;
Evande, R ;
Kabil, Ö ;
Ojha, S ;
Taoka, S .
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2003, 1647 (1-2) :30-35
[7]   Redox regulation and reaction mechanism of human cystathionine-β-synthase:: a PLP-dependent hemesensor protein [J].
Banerjee, R ;
Zou, CG .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2005, 433 (01) :144-156
[8]   Hydrogen sulfide in the mouse ductus arteriosus: a naturally occurring relaxant with potential EDHF function [J].
Baragatti, Barbara ;
Ciofini, Enrica ;
Sodini, Daria ;
Luin, Stefano ;
Scebba, Francesca ;
Coceani, Flavio .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2013, 304 (07) :H927-H934
[9]   Hydrogen sulfide is involved in dexamethasone-induced hypertension in rat [J].
Bianca, Roberta d'Emmanuele di Villa ;
Mitidieri, Emma ;
Donnarumma, Erminia ;
Tramontano, Teresa ;
Brancaleone, Vincenzo ;
Cirino, Giuseppe ;
Bucci, Mariarosaria ;
Sorrentino, Raffaella .
NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2015, 46 :80-86
[10]   Hydrogen Sulfide-Induced Dual Vascular Effect Involves Arachidonic Acid Cascade in Rat Mesenteric Arterial Bed [J].
Bianca, Roberta d'Emmanuele di Villa ;
Sorrentino, Rosalinda ;
Coletta, Ciro ;
Mitidieri, Emma ;
Rossi, Antonietta ;
Vellecco, Valentina ;
Pinto, Aldo ;
Cirino, Giuseppe ;
Sorrentino, Raffaella .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2011, 337 (01) :59-64