Enantioselective iridium-catalyzed allylic alkylations -: Improvements and applications based on salt-free reaction conditions

被引：45

作者：

Gnamm, Christian ^{[1
]}

Foerster, Sebastian ^{[1
]}

Miller, Nicole ^{[1
]}

Broedner, Kerstin ^{[1
]}

Helmchen, Guenter ^{[1
]}

机构：

[1] Univ Heidelberg, Inst Organ Chem, D-69120 Heidelberg, Germany

来源：

SYNLETT | 2007年 / 05期

关键词：

Taniguchi lactone; iridium; enantioselectivity; allylic substitution; catalysis;

D O I：

10.1055/s-2007-970754

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Simplified procedures for the Ir-catalyzed asymmetric allylic alkylation reaction are described that often allow substitution products to be obtained with >= 99% ee. Applications to syntheses of important chiral building blocks, such as the Taniguchi lactone and dimethyl 2-vinylcyclopropane-1,1-dicarboxylate, are presented.

引用

页码：790 / 794

页数：5

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