Ubiquitous Chromatin Opening Elements (UCOEs) prevent promoter silencing in retroviral vectors and boost transgene expression from adenoviral vectors

被引:0
作者
Lipinski, KS
Cliffe, S
Griffiths, M
Williams, S
Crombie, R
Mountain, A
Irvine, A
机构
[1] ML Labs PLC, Keele ST5 5SP, Staffs, England
[2] Kings Coll London, GKT Sch Med, Div Med & Mol Genet, Nucl Biol Grp, London SE1 9RT, England
关键词
D O I
暂无
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
27
引用
收藏
页码:S11 / S12
页数:2
相关论文
共 50 条
  • [41] Insulation from viral transcriptional regulatory elements improves inducible transgene expression from adenovirus vectors in vitro and in vivo
    D S Steinwaerder
    A Lieber
    Gene Therapy, 2000, 7 : 556 - 567
  • [42] Type and position of promoter elements in retroviral vectors have substantial effects on the expression level of an enhanced green fluorescent protein reporter gene
    M. Flasshove
    W. Bardenheuer
    A. Schneider
    G. Hirsch
    P. Bach
    C. Bury
    T. Moritz
    S. Seeber
    B. Opalka
    Journal of Cancer Research and Clinical Oncology, 2000, 126 : 391 - 399
  • [43] Cellular Antisilencing Elements Support Transgene Expression from Herpes Simplex Virus Vectors in the Absence of Immediate Early Gene Expression
    Han, Fang
    Miyagawa, Yoshitaka
    Verlengia, Gianluca
    Ingusci, Selene
    Soukupova, Marie
    Simonato, Michele
    Glorioso, Joseph C.
    Cohen, Justus B.
    JOURNAL OF VIROLOGY, 2018, 92 (17)
  • [44] Lentiviral vectors carrying enhancer elements of Hb9 promoter drive selective transgene expression in mouse spinal cord motor neurons
    Peviani, Marco
    Kurosaki, Mami
    Terao, Mineko
    Lidonnici, Dario
    Gensano, Francesco
    Battaglia, Elisa
    Tortarolo, Massimo
    Piva, Roberto
    Bendotti, Caterina
    JOURNAL OF NEUROSCIENCE METHODS, 2012, 205 (01) : 139 - 147
  • [45] Effect of Promoter Elements on Titers and Expression from HIV1-Based Gene Vectors in Lung Cells
    Himmel, Anne
    Aneja, Manish K.
    Rudolph, Carsten
    MOLECULAR THERAPY, 2009, 17 : S124 - S124
  • [46] Specific membrane receptor gene expression targeted with radiolabeled peptide employing the erbB-2 and DF3 promoter elements in adenoviral vectors
    Stackhouse, MA
    Buchsbaum, DJ
    Kancharla, SR
    Grizzle, WE
    Grimes, C
    Laffoon, K
    Pederson, LC
    Curiel, DT
    CANCER GENE THERAPY, 1999, 6 (03) : 209 - 219
  • [47] Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells
    Zhang, Fang
    Thornhill, Susannah I.
    Howe, Steven J.
    Ulaganathan, Meera
    Scharnbach, Axel
    Sinclair, Joanna
    Kinnon, Christine
    Gaspar, H. Bobby
    Antoniou, Michael
    Thrasher, Adrian J.
    BLOOD, 2007, 110 (05) : 1448 - 1457
  • [48] Specific membrane receptor gene expression targeted with radiolabeled peptide employing the erbB-2 and DF3 promoter elements in adenoviral vectors
    Murray A Stackhouse
    Donald J Buchsbaum
    Sreekanth R Kancharla
    William E Grizzle
    Christie Grimes
    Kim Laffoon
    Lee C Pederson
    David T Curiel
    Cancer Gene Therapy, 1999, 6 : 209 - 219
  • [49] Specific membrane receptor gene expression targeted with radiolabeled peptides employing the erbB-2 and DF3 promoter elements in adenoviral vectors
    Stackhouse, MA
    Kancharla, SR
    Buchsbaum, DJ
    Grimes, C
    Laffoon, K
    Pederson, LC
    Curiel, DT
    CANCER GENE THERAPY, 1997, 4 (06) : P96 - P96
  • [50] An erythroid-specific chromatin remodeling element increases β-globin gene expression from a series of retroviral gene transfer vectors.
    Nemeth, MJ
    Lowrey, CH
    BLOOD, 2001, 98 (11) : 439A - 439A