Correlation Between 25-Hydroxyvitamin D and Estradiol Serum Level in Determining Bone Density in Menopausal Women

Postmenopausal osteoporosis is one of the world's concern with high morbidity and mortality which is marked by low bone density which makes the bone fragile and increases the risk of fracture. It had be known that estrogen plays a role in women's bone health, that is to maintain the activity of osteoblasts and osteoclasts. Vitamin D which is reflected by 25 Hydroxyvitamin D (25(OH)D) serum is also known to be important to stimulate the absorbtion of calcium in the small intestine for bone mineralization and in the state of vitamin D deficiency, it increases bone turnover by causing secondary hyperparathyroidism. To know the correlation between 25(OH)D and estradiole serum level with bone densities in menopausal women. This is an analytic research with cross sectional approach performed on 36 menopaused midwives/nurses in RSUP. H. Adam Malik Medan, from September-October 2015. We measure the level of 25(OH)D and estradiole serum, bone density were measured using Dual energy X-ray Absorbtiometry (DXA) method, and then were analized with multiple correlation test. From the characteristics, it is found that most of them is aged > 50 (80,6%), menopause since 3-4 years ago (55,6%), normoweight BMI (47,2%), 25(OH)D level <= 20ng/ml (69,4%), estradiole level <= 20pg/ml(88,9%), and osteopenia (63,9%). Based on chi-square, from the risk factors, only Body Mass Index shows a significant correlation with bone densitiy and estradiole rate (p=0,015 and p=0,005). According to Spearman correlation test, there is no significant corelations between 25(OH)D serum level and T-score (r=0,261, p>0,05). There is a significant positive corelations between estradiole serum and T-score (r=0,53, p<0,05) and with multiple corelation test, there is a significant positive corelations between 25(OH)D rate and estradiole serum with T-score (R=0,0663 and p<0,05). Level of 25(OH)D and Estradiole serum have a contribution value as much as 44% towards bone density (R-2=0,44). There is a significant positive corelations between the level of 25(OH)D and estradiole serum towards bone density score (T-score).