The first synthesis of both enantiomers of [α-2H]phenylacetic acid in high enantiomeric excess

被引：14

作者：

Matoishi, K

Hanzawa, S

Kakidani, H

Suzuki, M

Sugai, T

Ohta, H

机构：

[1] Keio Univ, Dept Chem, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan

[2] Tosoh Corp, Tokyo Res Ctr, Ayase, Kanagawa 2521123, Japan

来源：

CHEMICAL COMMUNICATIONS | 2000年 / 16期

关键词：

D O I：

10.1039/b003941l

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Arylmalonate decarboxylase (EC. 4. 1. 1. 76) catalysed decarboxylation followed by enantioface-differentiating protonation of [alpha-H-2]- and [alpha-H-1]phenylmalonic acid in (H2O)-H-1 and (H2O)-H-2 respectively, gave highly enantiomerically enriched (R)- and (S)-[alpha-H-2]phenylacetic acid in quantitative yields.

引用

页码：1519 / 1520

页数：2

共 8 条

[1] CONVENIENT AND EFFICIENT PREPARATION OF AROMATIC ALPHA-HYDROPEROXY ACIDS VIA OXYGENATION OF ALPHA-LITHIO ENOLATES, PREPARED BY DIRECT ALPHA-LITHIATION OF ARYLACETIC ACIDS [J].