Hans van Houwelingen and the Art of Summing up

被引：41

作者：

Senn, Stephen ^{[1
]}

机构：

[1] Univ Glasgow, Dept Stat, Glasgow G12 8QW, Lanark, Scotland

来源：

BIOMETRICAL JOURNAL | 2010年 / 52卷 / 01期

关键词：

Bias; Bivariate model; Inter-trial information; Meta-analysis; Random effects; THERAPEUTIC ARTHRITIS RESEARCH; RANDOMIZED CONTROLLED-TRIAL; INDIVIDUAL PATIENT DATA; CLINICAL-TRIALS; METAANALYSIS; TARGET; EVENT; META; LUMIRACOXIB; IBUPROFEN;

D O I：

10.1002/bimj.200900074

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Some personal remarks about Hans van Houwelingen's approach to biostatistics in general are followed by a discussion of his article with Koos Zwinderman and Theo Stijnen outlining a bivariate approach to meta-analysis. It is concluded that this is more radical than many may realise in that it permits inter-trial information to be recovered. This has some advantages but in theory opens the door to bias. It is concluded that in practice the size of this bias is likely to be small. I end with some further personal remarks to Hans.

引用

页码：85 / 94

页数：10

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