Periconiastone A, an Antibacterial Ergosterol with a Pentacyclo[8.7.0.01,5.02,14.010,15]heptadecane System from Periconia sp. TJ403-rc01

被引：53

作者：

Gao, Weixi ^{[1
,3
]}

Chai, Chenwei ^{[1
]}

He, Yan ^{[4
]}

Li, Fengli ^{[1
]}

Hao, Xincai ^{[2
]}

Cao, Fei ^{[5
]}

Gu, Lianghu ^{[1
]}

Liu, Junjun ^{[1
]}

Hu, Zhengxi ^{[1
]}

Zhang, Yonghui ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Hubei Key Lab Nat Med Chem & Resource Evaluat, Sch Pharm, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China

[2] Hubei Univ Med, Coll Pharm, Shiyan 442000, Peoples R China

[3] Wuhan Univ, Renmin Hosp, Dept Pharm, Wuhan 430060, Hubei, Peoples R China

[4] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Hubei, Peoples R China

[5] Hebei Univ, Coll Pharmaceut Sci, Baoding 071002, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 20期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1021/acs.orglett.9b03270

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Periconiastone A (1), an ergosterol with an unprecedented pentacyclo [8.7.0.0(1,5)0(2,14).0(10,15)]heptadecane system, was isolated from Periconia sp. TJ403-rc01. Its structure was assigned by extensive spectroscopic analyses and quantum-chemical C-13 NMR and ECD calculations. A vinylogous alpha-ketol rearrangement and an aldol condensation reaction during biosynthesis were proposed as key steps for the formation of 1. Compound 1 showed antibacterial activity against Gram-positive S. aureus and E. faecalis with MIC values of 4 and 32 mu g/mL, respectively.

引用

页码：8469 / 8472

页数：4

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