Differential effects of natural and synthetic vitamin E on gene transcription in murine T lymphocytes

被引：38

作者：

Han, Sung Nim ^{[2
]}

Pang, Eunice ^{[1
]}

Zingg, Jean-Marc ^{[1
]}

Meydani, Simin Nikbin ^{[1
]}

Meydani, Mohsen ^{[1
]}

Azzi, Angelo ^{[1
]}

机构：

[1] Tufts Univ, JM USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA

[2] Seoul Natl Univ, Dept Food & Nutr, Coll Human Ecol, Seoul, South Korea

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2010年 / 495卷 / 01期

关键词：

RRR-alpha-tocopherol; Gene expression; Synthetic alpha-tocopherol; T-cell; TRANSFER PROTEIN-DEFICIENCY; ALPHA-TOCOPHEROL; GAMMA-TOCOPHEROL; CELL-PROLIFERATION; NUCLEAR RECEPTOR; OLD MICE; EXPRESSION; AGE; INHIBITION; NETWORKS;

D O I：

10.1016/j.abb.2009.12.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mice were supplemented with low and high doses of natural and synthetic vitamin E, T cells from the spleen isolated and stimulated with plate-bound anti-CD3 and soluble anti-CD28, and gene expression changes assessed by gene array experiments. The data obtained indicate significant qualitative and quantitative differences between the two vitamin forms in regulating gene expression in response to T-cell stimulation. Marker genes have been found whose expression can be considered significant in establishing the level of, and response to vitamin E for both natural and synthetic vitamin E supplementation; unique markers for synthetic vitamin E supplementation and unique markers for natural vitamin E supplementation have been identified. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：49 / 55

页数：7

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