The crucial roles of N6-methyladenosine (m6A) modification in the carcinogenesis and progression of colorectal cancer

被引：36

作者：

Fang, Zhihao ^{[1
]}

Hu, Yiqiu ^{[1
]}

Hu, Jinhui ^{[2
]}

Huang, Yanqin ^{[1
]}

Zheng, Shu ^{[1
]}

Guo, Cheng ^{[1
]}

机构：

[1] Zhejiang Univ, Canc Inst, Key Lab Canc Prevent & Intervent, Affiliated Hosp 2,China Natl Minist Educ,Sch Med, Hangzhou 310009, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Colorectal Surg, Sch Med, Hangzhou 310016, Zhejiang, Peoples R China

来源：

CELL AND BIOSCIENCE | 2021年 / 11卷 / 01期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

N-6-methyladenosine; RNA methylation; Coding and noncoding RNA; Colorectal cancer; MESSENGER-RNA METHYLATION; LONG NONCODING RNA; SINGLE-NUCLEOTIDE-RESOLUTION; NUCLEAR-RNA; UP-REGULATION; COLON-CANCER; PROMOTES; TRANSLATION; METTL3; N6-METHYLADENOSINE;

D O I：

10.1186/s13578-021-00583-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As the predominant modification in RNA, N-6-methyladenosine (m(6)A) has attracted increasing attention in the past few years since it plays vital roles in many biological processes. This chemical modification is dynamic, reversible and regulated by several methyltransferases, demethylases and proteins that recognize m(6)A modification. M(6)A modification exists in messenger RNA and affects their splicing, nuclear export, stability, decay, and translation, thereby modulating gene expression. Besides, the existence of m(6)A in noncoding RNAs (ncRNAs) could also directly or indirectly regulated gene expression. Colorectal cancer (CRC) is a common cancer around the world and of high mortality. Increasing evidence have shown that the changes of m(6)A level and the dysregulation of m(6)A regulatory proteins have been implicated in CRC carcinogenesis and progression. However, the underlying regulation laws of m(6)A modification to CRC remain elusive and better understanding of these mechanisms will benefit the diagnosis and therapy. In the present review, the latest studies about the dysregulation of m(6)A and its regulators in CRC have been summarized. We will focus on the crucial roles of m(6)A modification in the carcinogenesis and development of CRC. Moreover, we will also discuss the potential applications of m(6)A modification in CRC diagnosis and therapeutics.

引用

页数：11

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