Enantioselective Rauhut-Currier-Type 1,6-Conjugate Addition of Methyl Vinyl Ketone to para-Quinone Methides

被引：59
作者：
Kang, Tian-Chen [1 ,2 ]
Wu, Lu-Ping [1 ,2 ]
Yu, Qi-Wen [1 ,2 ]
Wu, Xin-Yan [1 ,2 ]
机构：
[1] East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China
[2] East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Shanghai 200237, Peoples R China
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2017年 / 23卷 / 27期
关键词：
asymmetric catalysis; chiral phosphine; conjugation; quinone methide; rauhut-currier; MORITA-BAYLIS-HILLMAN; MICHAEL CYCLOISOMERIZATION; ASYMMETRIC-SYNTHESIS; PHOSPHINE CATALYSIS; ACTIVATED ALKENES; ACID-ESTERS; ADDITION/AROMATIZATION; ORGANOCATALYSTS; CYCLIZATION; ALLENES;
D O I：
10.1002/chem.201700520
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An unprecedented Rauhut-Currier-type 1,6-conjugate addition has been developed. With chiral cyclohexane-based phosphine-amide catalyst 3h, the 1,6-conjugate reaction has been achieved to produce chiral diarylmethine compounds in excellent yields (91-99%) and enantioselectivities (92-98% ee).
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页码：6509 / 6513
页数：5
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