Swelling behavior of temperature- and pH-sensitive block terpolymers for drug delivery

被引：24
|
作者：
Vakkalanka, SK [1 ]
Peppas, NA [1 ]
机构：
[1] PURDUE UNIV,SCH CHEM ENGN,BIOMAT & DRUG DELIVERY LABS,W LAFAYETTE,IN 47907
来源：
POLYMER BULLETIN | 1996年 / 36卷 / 02期
关键词：
D O I：
10.1007/BF00294910
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Hydrogels prepared by block terpolymerization of N-isopropylacrylamide (NIPAAm), acrylic acid (AA) and 2-hydroxyethyl methacrylate (HEMA) exhibit significant temperature sensitivity due to the block structure of the NIPAAm moiety, even at concentrations as low as 10 mol%. pH-Sensitivity was also observed due to the ionizable AA component. The swelling ratio dependence on temperature is significantly more prominent for block terpolymers than for the corresponding random terpolymers.
引用
收藏
页码：221 / 225
页数：5
相关论文
共 50 条
  • [1] Temperature- and pH-sensitive terpolymers for modulated delivery of streptokinase
    Vakkalanka, SK
    Brazel, CS
    Peppas, NA
    JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 1996, 8 (02) : 119 - 129
  • [2] Temperature- and pH-sensitive polymeric micelles for drug encapsulation, release and targeting
    Sosnik, A. (alesosnik@gmail.com), 1600, Royal Society of Chemistry, Milton Road, Cambridge, CB4 OWF, United Kingdom (02):
  • [3] pH-sensitive biocompatible block copolymer vesicles for drug delivery
    Du, Jianzhong
    Tang, Yiqing
    Lewis, Andrew L.
    Armes, Steven P.
    JOURNAL OF CONTROLLED RELEASE, 2011, 152 : E16 - E17
  • [4] Temperature- and pH-Sensitive Multicolored Micellar Complexes
    Li, Yong-Yong
    Cheng, Han
    Zhu, Jing-Ling
    Yuan, Lin
    Dai, Yu
    Cheng, Si-Xue
    Zhang, Xian-Zheng
    Zhuo, Ren-Xi
    ADVANCED MATERIALS, 2009, 21 (23) : 2402 - +
  • [5] ABC Triblock Terpolymers Exhibiting Both Temperature- and pH-Sensitive Micellar Aggregation and Gelation in Aqueous Solution
    Koonar, Isha
    Zhou, Can
    Hillmyer, Marc A.
    Lodge, Timothy P.
    Siegel, Ronald A.
    LANGMUIR, 2012, 28 (51) : 17785 - 17794
  • [6] EQUILIBRIUM SWELLING BEHAVIOR OF PH-SENSITIVE HYDROGELS
    BRANNONPEPPAS, L
    PEPPAS, NA
    CHEMICAL ENGINEERING SCIENCE, 1991, 46 (03) : 715 - 722
  • [7] pH-Sensitive Biomaterials for Drug Delivery
    Zhuo, Shijie
    Zhang, Feng
    Yu, Junyu
    Zhang, Xican
    Yang, Guangbao
    Liu, Xiaowen
    MOLECULES, 2020, 25 (23):
  • [8] pH-sensitive polymers for drug delivery
    Huh, Kang Moo
    Kang, Han Chang
    Lee, Young Ju
    Bae, You Han
    MACROMOLECULAR RESEARCH, 2012, 20 (03) : 224 - 233
  • [9] PH-sensitive liposomes in drug delivery
    Paliwal, Shivani Rai
    Paliwal, Rishi
    Vyas, Suresh P.
    RSC Smart Materials, 2013, 1 (01): : 80 - 93
  • [10] Dynamic swelling Behavior of pH-sensitive anionic hydrogels used for protein delivery
    Kim, B
    La Flamme, K
    Peppas, NA
    JOURNAL OF APPLIED POLYMER SCIENCE, 2003, 89 (06) : 1606 - 1613
12345