Iron metabolism gene expression and prognostic features of hepatocellular carcinoma

被引：57

作者：

Shen, Ying ^{[1
,2
]}

Li, Xin ^{[1
,2
]}

Zhao, Bin ^{[1
,2
]}

Xue, Yanru ^{[1
,2
]}

Wang, Shenghang ^{[1
,2
]}

Chen, Xin ^{[1
,2
]}

Yang, Jiancheng ^{[1
,2
]}

Lv, Huanhuan ^{[1
,2
]}

Shang, Peng ^{[2
,3
]}

机构：

[1] Northwestern Polytech Univ, Sch Life Sci, Xian, Shaanxi, Peoples R China

[2] Northwestern Polytech Univ, Res & Dev Inst Shenzhen, Shenzhen 518057, Peoples R China

[3] Northwestern Polytech Univ, Sch Life Sci, Inst Special Environm Biophys, Key Lab Space Biosci & Biotechnol, Xian, Shaanxi, Peoples R China

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2018年 / 119卷 / 11期

基金：

中国国家自然科学基金;

关键词：

bioinformatics; hepatocellular carcinoma (HCC); iron metabolism; prognosis; TCGA; CELL-DEATH; CANCER; CARCINOGENESIS; FERROPTOSIS; PROTEIN; LIVER; INFLAMMATION; FERROPORTIN; BIOMARKERS; DISCOVERY;

D O I：

10.1002/jcb.27184

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Iron metabolism is crucial to hepatocellular carcinoma progression and is a key determinant of prognosis. Protein-protein interactions within the iron metabolism gene network were analyzed using the European Molecular Biology Laboratory's Search Tool for Recurring Instances of Neighbouring Genes/Proteins database. We obtained 423 liver hepatocellular carcinoma gene expression profiles from the Cancer Genome Atlas database. The expression and pathway enrichment of representative iron intake genes (TFRC and DMT1), utilization genes (FTH1, FTL, HIF1A, HMOX1, SLC25A37, and SLC25A38), and efflux genes (FLVCR1 and SLC40A1) was investigated in tumor and adjacent tissues. We determined the relationship between iron metabolism and the prognostic features of liver hepatocellular carcinoma. The liver metabolism genes TFRC and FLVCR1 were related to survival, disease status, and prognosis in patients with hepatocellular carcinoma. Our results provide novel insight into liver cancer therapy.

引用

页码：9178 / 9204

页数：27

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